BACKGROUND/AIMS Vascular calcification (VC), a major complication in humans and animals with chronic kidney disease (CKD), is influenced by changes in acid-base balance. The purpose of this study was to describe the acid-base balance in uremic rats with VC and to correlate the parameters that define acid-base equilibrium with VC. METHODS Twenty-two rats with CKD induced by 5/6 nephrectomy (5/...

While long term disturbances in the acid–base balance can disturb the normal growth and development, acute short term, but severe changes in pH, can also be drastic. The body's acid base balance is maintained by different organ systems, including the lungs and the kidneys, along with the intracellular and extracellular buffer systems. A human body’s normal pH ranges from 7.35-7.45. pH and hydro...

tion. The APS Constitution and Bylaws appears in the FASEB Membership Directory. Officers: President, Alfred P. Fishman, University of Pennsylvania Hospital, Philadelphia, PA; President-Elect, John B. West, University of California, La Jolla, CA; Past President, Walter C. Randall, Loyola University, Maywood, IL; Council, Alfred P. Fishman, John B. West, Walter C. Randall, Franklyn G. Knox, Jack...

There are many disorders/diseases that lead to changes in acid base balance. These conditions are not rare or uncommon in clinical practice, but everyday occurrences on the ward or in critical care. Conditions such as asthma, chronic obstructive pulmonary disease (bronchitis or emphasaemia), diabetic ketoacidosis, renal disease or failure, any type of shock (sepsis, anaphylaxis, neurogenic, car...

Two processes permit the urine pH and the medullary interstitial pH to remain in an "ideal range" to minimize the risk of forming kidney stones. First, a medullary shunt for NH(3) maintains the urine pH near 6.0 to minimize uric acid precipitation when distal H(+) secretion is high. Second, excreting dietary alkali excreting alkali as a family of organic anions--including citrate--rather than a...

OBJECTIVE Metabolic studies reveal that acidogenic diets increase bone resorption acutely. This study was conducted to examine associations between diet-induced changes in net acid excretion (NAE) and changes in serum parathyroid hormone (PTH), bone resorption, and calcium excretion over a longer period of 60 days. METHODS Forty healthy older men and women were given 0.75 g/kg of protein as m...

The prevalence of metabolic acidosis increases in Chronic Kidney Disease (CKD) patients ac‐ cording to the fall in glomerular filtration rate (GFR). In early stages of renal dysfunction acid retention is mainly due to the reduced tubular ammonium (NH4+) secretion. As GFR de‐ clines retention of organic acids (HSO4, HPO4) is also observed. The acid load resultant from diet and protein catabolism...

Robinson (1) studied the effect of age on the arterial blood gases and the acid-base balance of normal males from 5 to 91 years of age. In addition to the well known increase in oxygen combining capacity which occurs during childhood and adolescence, Robinson found moderately lower mean values for hemoglobin saturation in adults above 40 years of age, and slightly higher mean values for arteria...

BACKGROUND Nutrition has long been known to strongly influence acid-base balance. Recently, we have shown that it is possible to appropriately estimate the renal net acid excretion (NAE) of healthy subjects from the composition of their diets. AIM OF THE STUDY 1) To briefly present a physiologically based calculation model that allows a reasonable estimation of the analytically determined uri...