The acI lineage of the phylum Actinobacteria is the most abundant bacterial group in most freshwater lakes. However, due to difficulties in laboratory cultivation, only two mixed cultures and some incomplete single-amplified or metagenome-derived genomes have been reported for the lineage. Here, we report the initial cultivation and complete genome sequences of four novel strains of the acI lin...

The ability to predict the resistance of reinforced concrete (RC) structures progressive collapse as a result an interior column removal has become need in structural design. In general, three mechanisms characterize structure collapse, flexural action, compressive arch and tension catenary action. objective this study is investigate effects floor system configurations on collapse-resistance RC...

In this editorial to the IJHCS Special Issue on Animal-­‐Computer Interaction (ACI), we provide an overview of the state-­‐of-­‐the-­‐art in this emerging field, outlining the main scientific interests of its developing community, in a broader cultural context of evolving human-­‐animal ...

Autologous chondrocyte implantation (ACI) is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes. We have perform...

Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in many Ca signaling pathways and, as such, are emerging novel therapeutic and insecticidal targets. RyRs are so named because they bind the plant alkaloid ryanodine with high affinity and although it is established that ryanodine produces profound changes in all aspects of function, our understanding of the mechan...

The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis through interaction with hepatic transporters. To date, a relatively strong association between dru...

BACKGROUND Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA). However, we are yet to understand fully why some individuals do not respond well to this intervention. Identification of a reliable and accurate biomarker panel that can predict which patients are likely to respond well to ACI is needed in or...

This paper uses computational simulation to investigate the lateral load-displacement behavior and failure modes of a modern 14-story reinforced concrete (RC) core wall building. The design complies with minimum code requirements current California Building Code, which is based on ASCE 7–16 ACI 318–14. representation building, accounts for material nonlinearities all structural components, empl...