Background/Objectives: Diabetes mellitus impairs glucose homeostasis causing neurological disorders due to perturbation in utilization of glucose. The mechanisms responsible for failure of glycaemic control in diabetes need to be thoroughly elucidated and hence the present study was initiated. Material and Methods: Diabetes was induced in albino rat models with alloxan monohydrate (40 mg/Kg int...

A new series of some novel pyrazinamide condensed 1,2,3,4-tetrahydropyrimidines was prepared by reacting of N-(3-oxobutanoyl)pyrazine-2-carboxamide with urea/thiourea and appropriate aldehyde in the presence of catalytic amount of laboratory made p-toluenesulfonic acid as an efficient catalyst. Confirmation of the chemical structure of the synthesized compounds (4a-l) was substantiated by TLC, ...

We measured cholinesterase (EC 3.1.1.8) and 5'-nucleotidase (EC 3.1.3.5) activities in serum of 24 healthy laboratory staff during 12 months. Overall mean activities ranged from 5.3 to 13.4 kU/L for cholinesterase and 5.4 to 9.8 U/L for 5'-nucleotidase. Cholinesterase activity was significantly (p less than 0.01) higher for men than for women. 5'-Nucleotidase activity was significantly (p = 0.0...

Synthetic approaches for new nanocomposite materials with relatively high cholinesterase activity have been developed. The peculiarity of the formation of such systems is the introduction of cholinesterase into polymer with subsequent incorporation on the ready-made silica particles and into the polysiloxane matrixes during sol-gel synthesis. Evaluation of the cholinesterase activity has been f...

the present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of hypericum retusum aucher. the amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by hplc. total phenolic content of h. retusum seed extract was found more than fru...

The chemical composition of the essential oils of flower at the pre-flowering, full-flowering and post-flowering stage of A. annua was analyzed by GC and GC/MS and sixty-two components were identified. The main compounds in the pre-flowering oil were β-myrcene (37.71%), 1, 8-cineole (16.11%) and camphor (14.97%). The full-flowering oil contained predominantly caryophyllene (19.4%), germacrene D...

The n-hexane (HE), dichloromethane (DC), methanol (ME), ethanol 70% (ET), and methanol with Soxlhet apparatus (MS) extracts of Stachys lavandulifolia aerial parts were screened for their potential tyrosinase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity. ET and MS inhibited tyrosinase with IC50 values of 33.4 and 42.8 μg/mL, respectively. The phytochemical in...

BACKGROUND Memantine and cholinesterase inhibitors (ChEI) have distinct pharmacological actions, and interest in the use of combination therapy for Alzheimer's disease (AD) is increasing. OBJECTIVE To assess the available data on the use of memantine-ChEI combination and to develop evidence-based recommendations. METHOD A systematic literature review with detailed discussion of the current ...

This current study addresses the effect of diazinon on reversible kinetic parameters such as Michaelis-Menten constant (KS) and Vmax of bovine retinal acetylcholinesterase (AChE). The Ks for the hydrolysis of acetylthiocholine iodide by AChE was increased while Vmax was decreased than the control value in the presence of the diazinon. A LineweaverBurk plot, Dixon plot and their secondary replot...

Cadmium as potential environmental xenobiotics has been shown to cross blood brain barrier and to adversely influence the activity of AChE and hence the brain functions. In the present study, we have evaluated the impact of cadmium in vitro on the properties of AChE isolated from rat brain. The enzyme was found to be membrane bound and it could be successfully solubilized using 0.2% (v/v) Trito...