retardant. The gastric residence of conventional dosage form is typically short which transit rapidly through the small intestine in not more than 3h, thus rapid gastrointestinal (GI) transit phenomenon may consequently lead to reduction in the extent of absorption of various drugs. The present study was to develop mucoadhesive microsphere of aceclofenac and evaluate the effect of polymer conce...

This study aimed to improve the dissolution rate of aceclofenac and release drug in a controlled manner over period 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). wet granulation method different Tablets evaluated for vitro profile phosphate buffer with pH 6.8 (without enzymes). The thickness hardness 3.23 ± 0.035 3.28 0.008 mm 3...