There are conflicting reports on cancer risk associated with angiotensin-converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs). This retrospective cohort study was conducted to analyze the risk of cancer development in patients who received ACE inhibitors/ARBs as treatment for essential hypertension. Using the Taiwan National Health Insurance Research Database, 297,688 eligibl...

Angiotensin converting enzyme (ACE) 2 activity and angiotensin-(1-7) [Ang-(1-7)] levels are increased in experimental cirrhosis; however, the pathways of hepatic Ang-(1-7) production have not been studied. This study investigated the role of ACE2, ACE, and neutral endopeptidase (NEP) in the hepatic formation of Ang-(1-7) from angiotensin I (Ang I) and Ang II and their effects on portal resistan...

The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene might have consequences for the risks of vascular diseases. We examined the ACE genotype and the effects of a perindopril-based blood pressure-lowering regimen on macrovascular events, dementia, and cognitive decline among hypertensive and nonhypertensive patients with a history of cerebrovascular disease....

The phosphorylation of the short C-terminal cytoplasmic domain of the somatic angiotensin-converting enzyme (ACE) is involved in the regulation of enzyme shedding. We determined whether the phosphorylation of the cytoplasmic domain of ACE (ACEct) on Ser1270 regulates the cleavage/secretion of the enzyme by affecting its association with other proteins. ACE was associated with beta-actin and the...

1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

1. Hall D. The aspirin-angiotensin converting enzyme inhibitor trade off: to halve and halve not. J Am Coll Cardiol 2000;35:1808–12. 2. Latini R, Tognoni G, Maggioni AP, et al. Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the presence and absence of aspirin. J Am Coll Cardiol 2000;35:1801–7. 3. Antiplatelet Trialists’...

Angiotensin-converting enzyme (ACE) inhibitors are widely used as antihypertensives, remodeling agents in heart failure, to stop the progression of diabetic nephropathy, well for a variety other clinical purposes. Some side effects ACE recognized such dry cough, hypotension, hyperkaliemia, proteinuria, renal failure. Also, these substances known have wide range dermatological addition their adv...

background: angiotensin converting enzyme (ace) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin ii that is a vasoconstrictor and mitogen factor. to date, the role of angiotensin ii on regulating blood flow in inflamed joints has not been studied.   methods: acute and chronic joint inflammation was induced in rabbits by intra-articul...