Combinatorial worlds can be used to give an account of necessity and possibility. Both accessibility and similarity between worlds can be deened. In this paper, we claim that combinatorial worlds can form a knowledge representation framework, and provide an interesting approach to nonmonotonic reasoning and belief revision. We investigate such aspects of the combinatorial worlds framework as co...

In this paper a model for usability/accessibility evaluation methods for appliance in Web 3D social software is being introduced and exemplified by looking at the currently popular phenomenon Second Life. The social aspect of specific Web 3D functions/applications will be in focus, as well as the issue of accessibility which poses an important aspect in Virtual Reality (VR) worlds. This plays a...

Potential users of Assistive Technologies (AT) have little assistance in AT selection and support. This paper develops the concept of a Common Accessibility Profile (CAP) which can be used as the basis for selecting and supporting computer-related ATs. The CAP is based on a user-AT-system model focusing on improving accessibility to the interactions between users and systems. The CAP provides a...

Various approaches to providing blind users with access to graphical user interfaces have been researched extensively in the past 15 years, and yet accessibility is still facing many obstacles. Graphical environments such as X Windows offer a high degree of freedom to both the developer and the user, complicating the accessibility problem even more. Existing technology is largely based on eithe...

Mitosis entails global alterations to chromosome structure and nuclear architecture, concomitant with transient silencing of transcription. How cells transmit transcriptional states through mitosis remains incompletely understood. While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclear factors and chromatin features remain associated with individual ...

The neutral theory of molecular evolution predicts that variation within species is inversely related to the strength of purifying selection, but the strength of purifying selection itself must be related to physical constraints imposed by protein folding and function. In this paper, we analyzed five enzymes for which polymorphic sequence variation within Escherichia coli and/or Salmonella ente...

Geographic information systems (GIS) can be effectively utilized to carry out spatio-temporal analysis of spatial accessibility to primary healthcare services. Spatial accessibility to primary healthcare services is commonly measured using floating catchment area models which are generally defined with three variables; namely, an attractiveness component of the service centre, travel time or di...

We propose a multisided platform approach that is user-based but seeks to provide an infrastructure that supports all stakeholders, making it easier for vendors to design, market and support access features, products, and services and that makes it easier for consumers to find, secure, and use access features, products and services, individually or mixed, on any device they encounter. The syste...

Automated and semi-automated accessibility evaluation tools are key to streamline the process of accessibility assessment, and ultimately ensure software products, contents, and services meet accessibility requirements. Different evaluation tools may better fit different needs and concerns, accounting for a variety of corporate and external policies, content types, invocation methods, deploymen...

Purpose The mutation-independent strategy for hammerhead ribozyme (hhRz) or RNA interference (RNAi)-based gene therapeutics to treat autosomal dominant diseases is predicated on the hypothesis that a single therapeutic would equivalently suppress all/most of the diverse mutant mRNAs in patients with the disease phenotype. However, the hypothesis has not been formally tested. We address this thr...