Background: ABVD or escBEACOPP chemotherapy (CT) ± radiation is the treatment approach for Hodgkin lymphoma (HL) patients. As a result of improvement, long-term survivors and treatment-related complications are recognized, among which, gonadal insufficiency plays cenrtal role. Moreover, little known about kinetics function sex hormones during CT to guide contraceptive measures. Subjects Methods...

Internationally it has become increasingly common practice to modify escalated BEACOPP (eBPP) by replacing procarbazine with dacarbazine reduce haematopoietic stem cell and gonadal toxicity in Hodgkin lymphoma (HL) patients. A similar replacement of COPP (to COPDac) reduced conferred comparable long-term event-free survival children (EuroNet-PHL-C1 trial; Mauz-Körholz et al. Lancet Oncol 2021)....