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چکیده مقدمه: ناباروری زنان بیماری چند عاملی با زمینه ژنتیکی بنیادین است. ژن گیرنده هورمون فولیکولی ((FSHR بر بازوی کوتاه کروموزوم شماره دو قرار دارد. این ژن در سلول‌های گرانولوزا‌ی تخمدان بیان می‌شود و عاملی بایسته برای هماهنگی فرایش گناد‌ها، بلوغ جنسی و پدیدآوری گامت در دوره‌ی باروری است. رخداد جهش در این ژن می‌تواند سبب کاهش میزان پیوند لیگاند به گیرنده و سطح cAMP شود. هدف: بررسی پیوستگی پلی...
Alpha-lipoic acid (ALA) is a naturally-occurring compound that has shown promising antioxidant and anti-inflammatory effects in experimental and human studies. The aim of this study was to assess the efficacy of ALA in the management of patients with diabetes mellitus (DM).We searched Medline (via PubMed), EBSCO, Scopus, and Web of Science for relevant randomized controlled trials. Data o...
Differential distribution of nonbreeding Least Sandpipers (Calidris minutilla) according to sex, bill, and wing length was documented using capture data from six locations between California and Ecuador. The distribution of age classes did not vary with latitude. Females, which are slightly larger than males, migrated further south. Wing length increased toward the south for both males and fema...
before, though such high values are seen in cases of myeloproliferative diseases (Bases, 1962). The prostate was normal clinically and at post-mortem examination. Another cause of raised serum acid phosphatase is an extremely high level of alkaline phosphatase activity in the serum (Woodard, 1959), some of which persists even at an acid pH. The alkaline phosphatase, however, was never found to ...
Background: Photodynamic therapy (PDT) is a promising therapeutic modality for the treatment of cancer and other diseases. In this study, the epidermoid carcinoma cell line A431 and the normal fibroblasts were used to investigate whether gold nanoparticles (GNPs) can induce an increase in cell death during PDT using 5-aminolevulinic acid (5-ALA) as a photosensitizer.Methods: Human fibroblast an...
Acid Phosphatase On each of the 500 patients the total plasma acid phosphatase and its formaldehyde stable fraction were estimated, the latter by the method described by Abul Fadl and King (1948), with results as shown in Table II. In this the unit values to the left of the centre dark line are within the normal range whilst those on the right are in the "doubtful " or " prostatic cancer" group...
Background: Peroxisome Proliferators- Activated Receptor-Gamma2 (PPAR- γ2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism and insulin sensitivity. The aim of this study was to evaluate the association of the Pro12Ala polymorphism at the PPAR- γ2 gene in Iranian population with obesity. Methods: The genomic DNAs of the 156 subjects including obese and healthy i...
5-Aminolevulinic acid accumulated in the culture medium when Agmeneflum quadplicatum strain PR-6 was incubated in the presence of levulinic acid, a competitive inhibitor of 8-aminolevulinic acid dehydratase, and specifically labeled glutamate and glycine. The 8-aminolevulinic acid was purified using Dowex 50W-X8 and cleaved by periodate to yield succinic acid and formaldehyde. The distribution ...
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