Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia.    Methods: In this case-control study, peripheral blood samples from 100 AML and 10...

Aberrant systemic arteries supplying the intralobar pulmonary sequestration can become dilated and have atherosclerotic change. Computed tomography is very useful in demonstrating the aberrant artery. We report a case of intralobar pulmonary sequestration with giant branching aneurysmal aberrant artery, and demonstrated the discontinuity of the bronchus by 64-slice computed tomography, which ha...

BACKGROUND Vertebral artery variations are common in thoracic aortic patients. If patients have the aberrant left vertebral artery, the more difficult to determine the treatment modality. CASE PRESENTATION We report the case of a 63-year-old man with an aberrant left vertebral artery originating from an aneurysmal aortic arch. The patient underwent a successful hybrid thoracic endovascular ao...

The Driver Behaviour Questionnaire (DBQ) is widely used around the world to investigate driving behaviours. However, it has several different versions extracted from the 50-items Manchester driver behaviour questionnaire for variety of societies. This study aims to calibrate the DBQ for the Iranian driver population and explore their aberrant driver behaviour. In total, 524 participants (325 me...

Background: Aberrant chromosomes can cause azoospermia but little is known about its molecular mechanism. Our aim is to explore any possible genetic defective to explain a given male infertility. Materials and Methods: An azoopsermic male was identified in a 23 years old male. G-banding and FISH confirmed the karyotype as chromosome insertion (18:7) (q22.1; q36.2q21.11). NGS was performed to an...

BACKGROUND Differentiation between aberrant ventricular conduction and ventricular ectopy during atrial fibrillation (AF) is of etiologic, prognostic, and therapeutic importance. We developed a noninvasive technique to diagnose aberrant ventricular conduction and ventricular ectopy in AF. METHODS AND RESULTS We studied the Holter ECGs of 34 patients with paroxysmal AF and 62 patients with chr...

Integration of the DNA copy of the HIV-1 genome into a host chromosome is required for viral replication and is thus an important target for antiviral therapy. The HIV-encoded enzyme integrase (IN) catalyzes two essential steps: 3' processing of the viral DNA ends, followed by the strand transfer reaction, which inserts the viral DNA into host DNA. Raltegravir binds to IN and blocks the integra...

Mutations at splice sites or surrounding sequences have been reported to cause aberrant splicing. However, splicing errors can also occur without sequence alterations. We investigated three tumor suppressor genes for aberrant splicing in tumors. At a low frequency per exon it was found in five of seven of the investigated in-frame exons of the neurofibromatosis type 1 (NF1) gene, in two of thre...