نتایج جستجو برای: abc transporters

تعداد نتایج: 35243  

2017
Thangadurai Mani Catherine Bourguinat Roger K. Prichard

Dirofilaria immitis, a filarial nematode, causes dirofilariasis in dogs, cats and occasionally in humans. Prevention of the disease has been mainly by monthly use of the macrocyclic lactone (ML) endectocides during the mosquito transmission season. Recently, ML resistance has been confirmed in D. immitis and therefore, there is a need to find new classes of anthelmintics. One of the mechanisms ...

2008
Miriam Huls Frans G. M. Russel Rosalinde Masereeuw

ATP binding cassette (ABC) transporters are ATP-dependent membrane proteins predominantly expressed in excretory organs, such as the liver, intestine, blood-brain barrier, blood-testes barrier, placenta, and kidney. Here, they play an important role in the absorption, distribution, and excretion of drugs, xenobiotics, and endogenous compounds. In addition, the ABC transporters, P-glycoprotein (...

Journal: :Biochemical Society transactions 2015
Theresia A Schaedler Belinda Faust Chitra A Shintre Elisabeth P Carpenter Vasundara Srinivasan Hendrik W van Veen Janneke Balk

A small number of physiologically important ATP-binding cassette (ABC) transporters are found in mitochondria. Most are half transporters of the B group forming homodimers and their topology suggests they function as exporters. The results of mutant studies point towards involvement in iron cofactor biosynthesis. In particular, ABC subfamily B member 7 (ABCB7) and its homologues in yeast and pl...

Journal: :Frontiers in bioscience : a journal and virtual library 2007
Juergen J Wenzel Armin Piehler Wolfgang E Kaminski

During the past years, available evidence suggests that members of a novel family of structurally highly related multispan proteins, designated ABC A-subclass transporters, exert critical functions in the control of cellular lipid transport processes. Loss-of-function scenarios, thus far, have revealed pivotal roles of individual ABC A-transporters in specialized lipid secretory pathways of the...

Journal: :The Journal of biological chemistry 2005
Christoph O Randak Michael J Welsh

ABC transporters are remarkably versatile machines that move a wide array of substances, including both hydrophilic and hydrophobic molecules across membranes (1-4). They are constructed with a modular design; each transporter has two nucleotidebinding domains (NBDs) and two membrane-spanning domains (often comprising six transmembrane helices). The NBDs are highly conserved modules that intera...

Journal: :Essays in biochemistry 2011
I Barry Holland

This chapter concentrates mainly on structural and mechanistic aspects of ABC (ATP-binding cassette) transporters and, as an example of the physiological significance of these proteins, on lipid transport, vitally important for human health. The chapter considers those aspects of ABC transporter function that appear reasonably well established, those that remain controversial and what appear to...

Journal: :Biochemical Society Transactions 2015

Journal: :Journal of Biological Chemistry 2005

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