The 42 amino acid Alzheimer’s Ab peptide is involved in the progression of Alzheimer’s disease. Here we describe the effects of intracellular Ab, produced through its attachment to either end of a green fluorescent protein, in yeast. Cells producing Ab exhibited a lower growth yield and a heat shock response, showing that Ab fusions promote stress in cells and supporting the notion that intrace...

Welcoming natural isotopic abundance in solid-state NMR: probing π-stacking and supramolecular structure of organic nanoassemblies using DNP Katharina Märker, ab Subhradip Paul, ǁab Carlos Fernández-de-Alba,ab Daniel Lee,ab JeanMarie Mouesca,ab Sabine Hediger,abc Gaël De Paëpe*ab Univ. Grenoble Alpes, INAC, F-38000 Grenoble, France. CEA, INAC, F-38000 Grenoble, France. CNRS, MEM, F-38000 Grenob...

The recreational use of 3,4-methyl​enedioxy​methylamphetamine (MDMA) remains consistently high on a global level. This reinforces the importance early, rapid and accurate detection MDMA. work reports novel development rapid, ultrasensitive selective immunofluorescence nanobiosensor probe for To develop nanoprobe, heavy metal-free AuZnFeSeS alloyed quantum dots (QDs) were synthesized coated with...

BACKGROUND To investigate whether Stiff-person syndrome (SPS) and cerebellar ataxia (CA) are associated with distinct GAD65-Ab epitope specificities and neuronal effects. METHODS Purified GAD65-Ab from neurological patients and monoclonal GAD65-Ab with distinct epitope specificities (b78 and b96.11) were administered in vivo to rat cerebellum. Effects of intra-cerebellar administration of GAD...