Atopic dermatitis (AD) is featured with impaired skin barrier. The stratum corneum (SC) and the intercellular tight junctions (TJs) constitute permeability barrier, which essential to protect host water loss pathogen entrance. SC constantly renewed by differentiating keratinocytes through cornification, during autophagy contributes organelles nucleus elimination. human GSDMA its mouse homologs ...

In this paper, we introduce and investigate new subclasses of bi-univalent functions with respect to the symmetric points in U=z?C:z<1 defined by Bernoulli polynomials. We obtain upper bounds for Taylor–Maclaurin coefficients a2,a3 Fekete–Szegö inequalities a3??a22 these subclasses.

The transcription of the T5 first-step transfer genes A2 and A3 has been shown to proceed from right to left (i.e., from A3 to A2) on the T5 DNA molecule.

Background We assessed safety, immunogenicity and clinical activity of recombinant MAGE-A3 antigen combined with AS15 immunostimulant (MAGE-A3 immunotherapeutic) in association with dacarbazine in patients with metastatic melanoma. Methods In this open-label, phase I/II, uncontrolled multicentre trial conducted in Belgium and France, patients with MAGE-A3-positive melanoma received up to 24 d...

BACKGROUND & AIMS Single large (>5 cm) hepatocellular carcinoma (HCC) is classified as Barcelona Liver Clinic (BCLC) stage early stage (A). Yet, controversies exist whether single large HCC can be considered as early stage. We have analyzed long-term outcome to see which stage is appropriate for these patients. METHODS From 2005 to 2006, 1,546 consecutive patients who were newly diagnosed as ...

OBJECTIVES The designer antibacterial peptide A3-APO is efficacious in mouse models of Escherichia coli and Acinetobacter baumannii systemic infections. Here we compare the efficacy of the peptide with that of imipenem and colistin in A. baumannii wound infections after burn injury. METHODS CD-1 mice were inflicted with burn wounds and different inocula of A. baumannii, isolated from an injur...

Adenosine is released during tissue injury, ischemia and tumor growth, and promotes angiogenesis. Because mast cells accumulate in the proximity of new blood vessel development, we examined if they may contribute to adenosine-induced angiogenesis. We found that HMC-1 human mast cells express A2A, A2B, and A3 adenosine receptors. The adenosine agonist NECA (100 micromol/L) increased interleukin-...

The endothelial cell protein C receptor also exists in soluble form in plasma (sEPCR), resulting from ADAM17 cleavage. Elevated sEPCR levels are observed in subjects carrying the A3 haplotype, which is characterized by a Ser219Gly substitution in the transmembrane domain, rendering the receptor more sensitive to cleavage. Because sEPCR production is not completely blocked by metalloprotease inh...

AIM To verify the expression and methylation status of the MAGE-A1 and MAGE-A3 genes in colorectal cancer tissues and cancer cell lines. METHODS We evaluated promoter demethylation status of the MAGE-A1 and MAGE-A3 genes by RT-PCR analysis and methylation-specific PCR (MS-PCR), as well as sequencing analysis, after sodium bisulfite modification in 32 colorectal cancer cell lines and 87 cancer...

Two new problems of bivalent propositional logic are proposed here: firstly, to distinguish the sense of propositions, besides the logical value and secondly, to analyze the ”ponderal” difference between two parts of a proposition: subject-predicate. 1 Relational projections and extensions Let r = (A1, A2, A3, R) be a ternary relation (see [3]). Starting with this, we may define three binary re...