Epithelial damage greatly increases the flux of a low molecular weight tracer 99mtechnetium-diethylenetriamine penta-acetic acid (99mTc-DTPA) from tracheal lumen to venous-blood in anaesthetized sheep. We have now investigated whether epithelial damage induced by the detergent, Triton X-100, alters the effects of luminal histamine on blood flow and 99mTc-DTPA flux. The cervical trachea was fill...

A new family of 99mTc(I)- tricarbonyl complexes and 125I-heteroaromatic compounds bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy. Characterization of the DNA interaction, performed with the non-radioactive Re and 127I congeners, confirmed that all compounds act as DNA intercalators. Both classes of compounds induce double strand breaks (DSB) in plasmid DNA bu...

The aim of this study was to investigate the predictive role of the orbital somatostatin receptor scintigraphy with 99mTc-EDDA/HYNIC-TOC (99mTc-TOC) to detect clinical stage of Graves’ ophthalmopathy and the response to corticosteroid therapy. The subjects of the experiment were 46 patients with Graves’ ophthalmopathy (GO) and four volunteers without eye disease or GO as the normal group (NG). ...

BACKGROUND Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients. MATERIAL/METHODS Twenty PD patients (13 males, 7 females, median age: 62 year...

The diaminodithiol (DADT) ligand has been conjugated to the neuromuscular blocking agent benzovesamicol (BVM) in the 5-position. DADT-BVM 1 was synthesized by coupling of 5-aminomethylbenzovesamicol with a BCA thiolactone reagent. 99mTc radiolabeling of 1 with [99mTc]glucoheptonate gave a 4.7:1 mixture of two 99mTc complexes as determined by HPLC. Biodistribution data of the major [99mTc]-1 com...

Ziel: Ziel der Studie ist die Evaluation des diagnostischen Potenzials von Szintigrafie und Elastografie zur Detektion von Gewebsveränderungen in Schilddrüsenknoten nach Mikrowellenablation. Material und Methoden: Fünffunddreißig Patientenmit 39 Schilddrüsenknotenwurdenmit Mikrowellenablation unter Ultraschallkontrolle behandelt. Die Elastografie und Szintigrafie wurde vor und nach Mikrowellena...

The clinical, left ventricular and coronary angiographic data, and the technetium-99m stannous pyrophosphate (99mTc-PYP) myocardial scintigraphic results are presented in 31 patients with unstable angina pectoris. One-third of these patients had positive 99mTc-PYP myocardial scintigrams in a pattern suggesting limited and diffuse subendocardial necrosis. The positive 99mTc-PYP myocardial scinti...

OBJECTIVE Primary hyperparathyroidism (pHPT) is characterised by increased parathyroid hormone (PTH) secretion and consequently increased plasma calcium. During the last few decades parathyroid scintigraphy (PS), is applied in almost all patients with pPHT before surgery and specifically before minimally invasive parathyroidectomy. The aim of this study was to find the best cut-off levels of to...

background: technetium-99m radioisotope is the backbone of any nuclear medicine institute. this radioisotope is acquired by the elution of molybdenum-99/technetium-99m generator which emits 141 kev gamma ray and having 6.04 hour half-life. occasionally the contents of molybdenum-99 may mix up with elute, which may affect image quality and patients may receive higher doses than recommended. this...