Abstract Aim There is limited information on outcomes of pT3a RCC treated with PN. Retrospective studies cT1/2 upstaged to RN vs PN show contradictory results. Method analysis all renal tumours removed by either or between 2000-2020 at a single centre performed 6 surgeons median follow up period 4 years. Results 186 cases were and 78 was CT suspicion T3a disease in 1 cases. The mean tumour size...

In Asia, young-onset type 2 diabetes (YOD) is characterized by obesity and increased risk for cardiovascular disease (CVD). In a genome-wide association study (GWAS) of 99 Chinese obese subjects with familial YOD diagnosed before 40-year-old and 101 controls, the T allele of rs1408888 in intron 1 of DACH1(Dachshund homolog 1) was associated with an odds ratio (OR) of 2.49(95% confidence interva...

Objectives—To study mortality and prevalence of neuropsychological symptoms among a cohort of painters known to have been heavily exposed to organic solvents. Methods—A mortality study of 1292 male painters who had worked in a dockyard in Scotland for >1 year between 1950 and 1992 comprised a nested cross sectional study of 953 surviving painters from the cohort and 953 male non-painters random...

BACKGROUND The frequency of BRCA1 germline mutations among Chinese women with triple-negative breast cancer is unclear, and the association between BRCA1 mutations and the response to neoadjuvant chemotherapy in women with triple-negative breast cancer has not been determined. PATIENTS AND METHODS Nine hundred and fifty-six triple-negative breast cancer patients were treated at our institute ...

OBJECTIVES To identify the normal baseline preoperative range of cerebral tissue oxygen saturation (SctO2) derived using near-infrared spectroscopy (NIRS) and the efficacy of perioperative interventions designed to modulate SctO2 in cardiac surgical patients. DESIGN Systematic review and meta-analysis of relevant randomized controlled trials (RCTs) extracted from the Medline, Embase, and Coch...

OBJECTIVES The benefit of intravenous recombinant tissue plasminogen activator (rt-PA) therapy for very old patients with acute ischemic stroke remains unclear. The aim of this study was to elucidate the efficacy and safety of intravenous rt-PA therapy for patients over 80 years old. METHODS Of 13,521 stroke patients registered in the Fukuoka Stroke Registry in Japan from June 1999 to Februar...

OBJECTIVES To study mortality and prevalence of neuropsychological symptoms among a cohort of painters known to have been heavily exposed to organic solvents. METHODS A mortality study of 1292 male painters who had worked in a dockyard in Scotland for > or = 1 year between 1950 and 1992 comprised a nested cross sectional study of 953 surviving painters from the cohort and 953 male non-painter...

BACKGROUND Tuberculosis (TB) remains one of the leading causes of death among infectious diseases worldwide. Despite its low incidence rates in countries of Western Europe and North America, the resurgence of TB in Eastern Europe and the increased immigration from high-incidence countries imply that extreme vigilance is required in order to detect early, treat, and isolate all new cases. In thi...

West Nile Virus (WNV) is a neurotropic flavivirus that can cause debilitating diseases, such as encephalitis, meningitis, or flaccid paralysis. We report the safety, pharmacokinetics, and immunogenicity of a recombinant humanized monoclonal antibody (MGAWN1) targeting the E protein of WNV in a phase 1 study, the first to be performed on humans. A single intravenous infusion of saline or of MGAW...

Abstract This study to determine the physicochemical properties of Nusa Tenggara Timur (NTT) forest honey from Apis Dorsata based on differences in moisture content. The method used was an experimental with a completely randomized design four treatments and replications. treatment given NTT content 23% reduced vacuum evaporator 22%, 21% 20%. variables observed were viscosity, pH Total Dissolved...