BACKGROUND HIF-1 activates various genes in cancer progression and metastasis. HIF-1α 1772 C/T and 1790 G/A polymorphisms are reportedly associated with cancer risk; however, the results are inconclusive. METHODOLOGY/PRINCIPAL FINDINGS A meta-analysis of 34 studies that involved 7522 cases and 9847 controls for 1772 C/T and 24 studies that involved 4884 cases and 8154 controls for 1790 G/A wa...

Recently, a number of studies have reported the association between the single nucleotide polymorphisms (SNPs) +45 T>G polymorphism in the adiponectin (ADIPOQ) gene and type 2 diabetes mellitus (T2DM) risk, though the results are inconsistent. In order to obtain a more precise estimation of the relationship, a meta-analysis was performed. In this current study, the Medline, Embase, Pubmed, ISI ...

BACKGROUND Small studies have yielded divergent results for administration of granulocyte colony-stimulating factor (G-CSF) after acute myocardial infarction. Adequately powered studies involving patients with at least moderate left ventricular dysfunction are lacking. METHODS Patients with left ventricular ejection fraction less than 45% after anterior-wall myocardial infarction were treated...

BACKGROUND The best strategy to identify women with gestational diabetes mellitus (GDM) is unclear. OBJECTIVES To perform a systematic review to calculate summary estimates of the sensitivity and specificity of the 50-g glucose challenge test for GDM. SEARCH STRATEGY Systematic search of MEDLINE, EMBASE and Web of Science. SELECTION CRITERIA Articles that compared the 50-g glucose challen...

OBJECTIVE To assess the association between myeloperoxidase (MPO) gene polymorphism and coronary artery disease (CAD). METHODS Several databases were used to retrieve relevant literature up to March 2013 by keywords. A Meta-analysis was performed by Stata12.0 software to estimate the pooled odds ratio (OR) and the 95% confidence interval (CI). Heterogeneity among studies was tested and sensit...

The tumor necrosis factor-alpha (TNF-α) G-308A polymorphism has been suggested to be a susceptibility factor for myocardial infarction (MI). However, differing results from various studies have led to controversial conclusions. Hence, we performed a meta-analysis to evaluate the association between TNF-α G-308A polymorphism and MI. Reported studies published before March 30, 2015 were included ...

In the original version of this article, the authors were incorrectly represented. The correct list of authors is provided below.

RWMODELII simulates the Rescorla-Wagnermodel oj Pavlovian conditioning, lt is written in Delphi and runs under Windows 3,1 and Windows 95, The program was designed[or novice and expert users and ?an beemr:loyed in teaching as well as in research. It is user jnendly and require~ a minimal level ofcomputer literacy but is sujjiciently flexible to permit a wide range of simulations. It allows the ...

Single nucleotide polymorphisms (SNPs) in energy metabolism related gene may be key agents in the development of human malignancies. In this study, we aimed to examine the association of transcription factor 7-like 2, Leptin (LEP) and LEP receptor (LEPR) polymorphisms with esophageal squamous cell carcinoma (ESCC). A total of 507 ESCC cases and 1,496 controls were enrolled. We found that LEPR r...

XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influence the risk of HCC. The association between the XRCC1 polymorphisms and t...