H- and Cl-terminal groups of bicyclo[2.2.2]octane (BCO) derivatives in a mixed self-assembled monolayer (SAM) on Au(111) were imaged using a modified Si tip with a CaF(2) nanocluster to differentiate the two terminals, which have different electronegativities. In order to achieve this we fabricated a new sample holder, on which a CaF(2) single crystal and the mixed SAM on Au(111) could be mount...

Phenylpropanoids may act as nonsteroidal anti-inflammatory drug (NSAID)-like compounds. 4-cis, 8-cis-Bis (4-hydroxy-3-methoxyphenyl)-3, 7-dioxabicyclo-[3.3.0]octane-2,6-dione (bis-FA, compound 2), a dimer of ferulic acid, was synthesized from ferulic acid (1), and its effect on lipopolysaccharide (LPS)-stimulated cyclooxygenase-2 (COX-2) expression in RAW 264.7 cells was compared with those of ...

(R)-1,2-Diaminobicyclo[2.2.2]octane was used as a starting material for the preparation, in solution or ball mill, of salen ligand. Five metal complexes were prepared high yield and their cytotoxic activities evaluated against Human Colon cancer HCT116 cell lines. The original manganese complex displayed highest activity with potency 16 fold higher than that cisplatin, demonstrating benefit bri...

Flash vacuum pyrrolysis of vinyl epoxides provides cis-dihydrofuran carboxylic esters in good yields and diastereoselectivities, which, on base-promoted epimerisation afford the complementary trans series. The compounds provide a viable template for a Lewis acid promoted cyclisation to provide the 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane core found in the furofuran series of natural lignans. Th...

Toluene oxidation activity in Pseudomonas mendocina KR1 and Pseudomonas sp. strain ENVPC5 was induced by trichloroethylene (TCE), and induction was followed by the degradation of TCE. Higher levels of toluene oxidation activity were achieved in the presence of a supplemental growth substrate such as glutamate, with levels of activity of up to 86% of that observed with toluene-induced cells. Act...

A new lignan glucoside was isolated from defatted sesame seed flour and its structure was established as sesamolinol diglucoside [2-(3-methoxy-4-(O-beta-D-glucopyranosyl (1-->6)-O-beta-D-glucopyranoside)phenoxyl)-6-(3,4-methylenedioxyphenyl)-cis-3,7-dioxabicyclo-(3.3.0)-octane] by mass and nuclear magnetic resonance spectroscopy. A quantitative analysis of 65 sesame seed samples showed that thi...

Essential oil of Baru Cina leaves (Artemisia vulgaris L.) has been successfully isolated by hydrodistillation method using the Stahl apparatus. were for ± 6 hours to produce essential amount 0.39 % (v/b). The obtained from was characterized GC-MS spectroscopy. analysis results showed that there 29 compounds and main identified as many 14 compounds, such Alpha-Pinene (0.33%), 1,8-Cineol (1.96% )...