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38997.htm; Accessed on 27/07/2005. 76) Puripattanavong J., Weber S., Brecht V., Frahm A. W., Planta Med., 66, 740—745 (2000). 77) Mulholland D. A., Randrianarivelojosia M., Lavaud C., Nuzillard J. M., Schwikkard S. L., Phytochemistry, 53, 115—118 (2000). 78) Hallur G., Sivaramakrishnan A., Bhat S. V., J. Nat. Prod., 65,
Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans
Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin. In the proximity of its target cells, high molecular weight kininogen (H-kininogen) is the substrate of plasma kallikrein, which releases bradykinin from H-kininogen. Heparan sulfate proteoglycans (HSPGs) play a critical role in either recruiting kinin precursors from the plasma, or in the assembly of ...
Human H-kininogen (120 kDa) plays a role in many pathophysiological processes and interacts with the cell surface through protein receptors and proteoglycans, which mediate H-kininogen endocytosis. In the present work we demonstrate that H-kininogen containing bradykinin domain is internalized and different endogenous kininogenases are present in CHO-K1 cells. We used CHO-K1 (wild type) and CHO...
1 Department of Pediatrics, Mures County Clinical Hospital, University of Medicine and Pharmacy of Tirgu-Mures, Romania 2 Department of Pediatrics, Mures County Emergency Clinical Hospital, University of Medicine and Pharmacy of Tirgu-Mures, Romania Corresponding author: Adrienne Horvath 38 Gheorghe Marinescu street, 540139, Tirgu-Mures, Romania, tel. +40 745 593380 E-mail: [email protected] A...
Alexander Larin 1,2, Phillip C. Womble 1 and Vladimir Dobrokhotov 3,* 1 VAON LLC, KY, USA, 2200 Lapsley Lane, Bowling Green, KY 42103, USA; [email protected] (A.L.); [email protected] (P.C.W.) 2 Department of Physics and Astronomy, University of Louisville, Louisville, KY 40292, USA 3 Applied Physics Institute, Western Kentucky University, Bowling Green, KY 42101, USA * Correspon...
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