One of the major binding sites for factor VIII inhibitors is located within the A2 domain. In this study, phage display technology was used to isolate 2 human monoclonal antibodies, termed VK34 and VK41, directed toward the heavy chain of factor VIII. The V(H) domain of a single-chain variable domain antibody fragment (scFv) VK34 is encoded by germline gene segment DP-10. Epitope-mapping studie...

We investigated the mechanisms that induce atrophy of the chicken bursa of Fabricius (BF) upon lipopolysaccharide (LPS) treatment in young chicks. LPS treatment resulted in ∼36% decrease in bursal weight within 36 h (P < 0.01). Histological analysis showed infiltration of eosinophilic heterophils and nucleated oval shaped RBCs in or near blood vessels of the BF from LPS-treated chicks. Scanning...

In this paper we investigate how strategic aspects in uence the choice between exporting and servicing foreign markets by setting up a plant in the foreign country. We show that tari s on imports in conjunction with the size of the set up costs incurred while setting up plants and the size of the foreign market will determine whether domestic rms which face competition from a foreign rm will ch...

Inherited genetic variation plays a critical but largely uncharacterized role in human differentiation. The completion of the International HapMap Project makes it possible to identify loci that may cause human differentiation. We have devised an approach to find such ethnically variant single-nucleotide polymorphisms (ESNPs) from the genotype profile of the populations included in the Internat...

Almost one-third of all proteases can be classified as serine proteases, named for the nucleophilic Ser residue at the active site. This mechanistic class was originally distinguished by the presence of the AspHis-Ser “charge relay” system or “catalytic triad”.1 The Asp-His-Ser triad can be found in at least four different structural contexts, indicating that this catalytic machinery has evolve...

AIMS The susceptibility patterns of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, and Streptococcus pyogenes isolated from specimens submitted to 12 private laboratories in South Africa were determined. METHODS Minimum inhibitory concentration (MIC) determinations were performed on the isolates in the microbiology laboratory at Tygerberg Hospi...

1. Khod AS, Thompson MH. Visceral leishmaniasis contracted in the Mediterranean area. Arch Dis Child 1983; 58 : 930-931. 2. Manson Bahr PEC, A,pted FLC. Manson's Tropical Diseases. 18th edition. London : Balliare Tindall. 1982 : 93-104. 3. Cachia EA, Fenech FF. A review of kalaazar in Malta from 1947 to 1962. Trans R Soc Trop Med Hyg 1964; 58 : 234-241. 4. Ozsoylu S, Hicsonmez G. Mediterranean ...

Banding textures are commonly observed in mineral crystals for example in sphalerites in Mississippi Valley-type deposit. Cellular Nonlinear Network (CNN) has been developed in the literature for characterizing complexity especially for reaction-diffusion dynamic systems. These include models describing periodic precipitation incorporating nucleation and banding pattern formation in minerals. B...

Human herpesvirus 8 (HHV-8) infection is very prevalent in sub-Saharan Africa, but the role of sexual transmission has not been well characterized. HHV-8 seroprevalence and correlates were evaluated in a cohort of female prostitutes in Mombasa, Kenya. Between February 1993 and January 2000, stored plasma samples taken from 736 women were tested, by whole-virus ELISA assay, for the presence of H...