How proteins with new functions (e.g., drug or antibiotic resistance or degradation of man-made chemicals) evolve in a matter of months or years is still unclear. This ability is dependent on the induction of new phenotypic traits by a small number of mutations (plasticity). But mutations often have deleterious effects on functions that are essential for survival. How are these seemingly confli...

Renal clearance (CLR), a major route of elimination for many drugs and drug metabolites, represents the net result of glomerular filtration, active secretion and reabsorption, and passive reabsorption. The aim of this study was to develop quantitative structurepharmacokinetic relationships (QSPKR) to predict CLR of drugs or drug-like compounds in humans. Human CLR data for 382 compounds were ob...

A silage inoculant [Biomin® BioStabil Plus, BSP, a blend of Enterococcus faecium (DSM 3530), Lactobacillus brevis (DSM 19456) and Lactobacillus plantarum (DSM 19457)], was used on legume-grass silage [32% of dry matter (DM)] vs. an untreated control silage (CT). The material had mean crude protein (CP) and water soluble carbohydrate (WSC) concentrations of 174 and 88 g/kg,respectively. BSP resu...

In recent decades, emerging evidence demonstrates that ultraconserved elements (UCEs) encoding noncoding RNAs serve as regulators of gene expression. Until now, the role of uc.189 in human cancers remains undefined and the clinical significance of uc.189 in gynecological cancers remains unknown. This study was to identify the prognostic value of uc.189 expression in gynecological cancers. Tissu...

In the paper, we study value distribution of differential polynomial Afn f(k) + Bf n+1 -1, where f is a transcendental meromorphic function and n(? 2),k(?2) are positive integers. We prove an inequality for Nevanlinna characteristic T(r,f) in terms reduced counting only. The result paper not only improves due to Q.D. Zhang [J. Chengdu Ins. Meteor., 20(1992), 12-20], also partially recent H. Kar...

Objetivo: Analisar o Manual Diagnóstico e Estatístico de Transtorno Mentais (DSM) enquanto um dispositivo info-comunicacional. Método: Realizou-se uma pesquisa bibliográfica, abordagem qualitativa. O DSM foi analisado a partir da proposta Foucault (1977), para quem é definido pela estrutura seus elementos heterogêneos sua gênese. Resultado: A primeira edição do Manual, DSM-I, elaborada então Am...

Soil scientists can aid in an essential part of ecological conservation and rehabilitation by quantifying soil properties, such as organic carbon (SOC), is stock (SOCs) SOC crucial for providing ecosystem services, and, through effective C-sequestration, the effects climate change be mitigated. In remote mountainous areas with complex terrain, northern Maloti-Drakensberg South Africa Lesotho, d...