In this study we examined whether lesions of rats' dorsal noradrenergic bundles affect their reaction times to temporally unpredictable stimuli. Injection of 6-hydroxydopamine into rats' dorsal bundles drastically reduced the noradrenaline content of their cerebral cortex. Nevertheless, 6OHDA treated rats could still react as quickly as controls. Moreover, the treatment did not affect the effic...

Abstract Parkinson’s disease (PD) is the second-most common neurodegenerative worldwide. Several studies have investigated PD for decades; however, exact mechanism of development remains unknown. To study PD, SH-SY5Y cells are often treated with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenylpyridinium (MPP+) to induce PD. understand pathogenesis, we confirmed protein changes between 6-OHDA- an...

Abstract: Aim/Background: Parkinson’s Disease (PD), the loss of dopaminergic neurons in substantial nigra part brain leading to neurodegeneration. Materials and Methods: The objective this study was observe neuroprotective effect synthesized derivatives 6-hydroxydopamine (6-OHDA) induced rat model. Here, designed naphthalene substituted azetidinone compounds defended lesions caused by 6-OHDA mo...

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Background: Parkinson’s disease (PD) is most commonly modelled in rats via injection of the neurotoxin 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Assessment of lateralised choice reaction time is usually conducted in the 9 hole box, a highly specialized apparatus that is not widely available in many behavioural laboratories. The retractable lever Skinner box on the other hand ...

The purpose of this study was to determine if caffeine augments the slow-pressor response to chronic low-dose infusions of angiotensin II (All) or the rapid-pressor response to acute infusions of All. All was infused (125 ng/min i.p.) for 12 d via miniosmotic pumps in four groups of rats: group I, intact rats not treated with caffeine (n = 9); group II, intact rats treated with caffeine (0.1% i...

PURPOSE To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. MATERIAL/METHODS 6-hydroxydopamine was used to lesion dopamine terminals within the core and shell accumbens. Experiment 1 assessed conditioning to a tone conditioned stimulus that had previously been paired with footshock (...

In this study, we demonstrate that human neuroblastoma SH-SY5Y cells transfected with human tyrosine hydroxylase isoform 1 (SH + TH cells) were substantially more resistant to cell death induced by hydrogen peroxide and 6-hydroxydopamine when compared to wild-type SH-SY5Y cells (SH cells). SH + TH cells exhibit increased levels of dopamine (DA) compared to SH cells. Incubation with hydrogen per...

Parkinson's disease (PD) is characterized by a myriad of symptoms, encompassing both motor disabilities and cognitive impairments. Recent research has shown that abscisic acid (ABA) phytohormone found in various brain regions several mammals exhibits neuroprotective properties. To investigate the effects ABA on disorders, mouse model PD was utilized. The administration 6-hydroxydopamine (6-OHDA...