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12-O-Tetnadecanoyl-phonbol-13-acetate (TPA) and phon bol were tested in Chinese hamster cells for their effects on mutagenesis (resistance to 6-thioguanine and to ouabain), DNA repair, and survival after ultraviolet (UV) irradiation. Recovery of 6-thioguanineand ouabain-resistant colonies was significantly increased by TPA treatment and, to a lessen extent, by phonbol in UV-innadiated cells. Mo...

A series of subpopulation lines derived from a single mouse mammary tumor were tested for their ability to interact with each other in metabolic cooperation assays in three-dimensional collagen gel cultures. Inhibition of growth in the presence of selective drug (6-thioguanine or 2-fluoroadenine) of two 6-thioguanine-resistant cell lines, 66cl4 and 44FTO, as well as a 2-fluoroadenine-resistant ...

When Ca-755 tumors of various sizes were treated with three doses of C14-labeled 6-thioguanine (10 mg/kg at 24-hour intervals) the specific activities of their deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) at the end of the treatment were independent of the starting size of the tumor. During the subsequent rapid tumor regression the specific activity of DNA and RNA decreased linearly w...

BackgroundChildhood acute lymphoblastic leukemia (ALL) maintenance therapy with oral 6-mercaptopurine (6-MP) and methotrexate prevents leukemic relapse by acting against residual lymphoblasts. Non-adherence to significantly increases ALL risk. The levels of intracellular 6-MP metabolites erythrocyte incorporated (ery-) thioguanine nucleotides (ery-TGN) methylated (ery-MeMP) can be used evaluate...