Treatment of cultured L1210 cells with the putrescine analogue, 2,5-diamino-3-hexyne, at 0.5 nM resulted in the rapid (1-2 h) appearance of numerous cytoplasmic vacuoles which were highly visible by light microscopy. Ultrastructural examination revealed that the vacuoles contained numerous membrane vesicles and electron-dense structures resembling endosomal elements. Other cellular organelles w...

Helix formation in a 17-residue alanine-lysine peptide and analogous peptides with specific lysine --> X substitutions, where X is 2,3-diamino-L-propionic acid, 2, 4-diamino-L-butyric acid or L-ornithine, have been examined using circular dichroism measurements. The dependence of helix content on X, its position in the sequence, and the number of lysine --> X substitutions are reasonably well d...

In this paper, an efficient method for synthesis of aromatic polyesters containing schiff base units is described by preparation of two polyesters. These polyesters have been prepared by the reaction of terephthaloyl dichloride on Schiff bases derived from p-hydroxybenzyldehyde and 4,4-diamino diphenyl ether, 4,4-diamino diphenyl methane. The Polymers were characterized by IR, CHNS, thermal...

The present communication reports the chemistry of three linear triborane(5) compounds possessing bulky diamino substituents on the terminal boron atoms. Fluorotriborane 2 was synthesized by a reaction of boryllithium and BF(3)·OEt(2). Halogen exchange reaction of 2 took place by a treatment with ClSiMe(3) to give the corresponding chlorotriborane(5) 3. Addition of silver tetraarylborate to 3 i...

In the title compound, [Pb(NO(3))(2)(C(6)H(6)N(4)S(2))(2)]·2H(2)O, the Pb(II) cation is N,N'-chelated by two 2,2'-diamino-4,4'-bi-1,3-thia-zole (DABT) ligands and further is cis coordinated by two nitrate anions in a distorted PbN(4)O(2) octa-hedral geometry. One of the uncoordinated water mol-ecules is close to an inversion center and is disordered equally over two sites. Intra-molecular N-H⋯N...

The effect of delta9-tetrahydrocannabinol (THC), the major psycho-active component of marijuana, in human prostate cancer cells PC-3 was investigated. THC caused apoptosis in a dose-dependent manner. Morphological and biochemical changes induced by THC in prostate PC-3 cells shared the characteristics of an apoptotic phenomenon. First, loss of plasma membrane asymmetry determined by fluorescent...