B3LYP/6-31+G level computations were performed for the formation of four trimethylammonium salts in the reaction of methyl chloride (1a), (S)-1,4-andydro-5-chloro-2,3,5-trideoxypentitol (2a), (2S,5S)-2,5-andydro-6-chloro-1,3,4,6-tetradeoxyhexitol (3a) and methyl 5-chloro-2,3,5-trideoxy-β-D-pentofuranoside (4a) with trimethylamine. All the structures were fully optimized in the gas phase, in chl...

To identify the possible roles of Ca2+-related proteins, calmodulin and microfilaments in leukemic cells, we tested the effect of calmodulin antagonists and cytochalasins on proliferation and differentiation of human promyelocytic leukemic HL-60 cells. The growth of HL-60 was inhibited by A/-(6-aminohexyl)-5-chloro-1 naphthalenesulfonamide, A/-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide, a...

A series of 3-[2'-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5-10), 3-[2'-(3(″)-chloro-2(″)-oxo-4(″)-substitutedphenylazetidin-1(″)-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11-16), and 3-[2'-(2(″)-substitutedphenyl-4(″)-oxo-1(″),3(″)-thiazolidin-3(″)-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17-22) have been synthesized in the present stu...