UNLABELLED Serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of 5-HT1A agents currently in human use (11C-labeled N-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-(2-pyridinyl)cyclohexanecarboxamide [11C-WAY-100635], 4-(2'-methoxyphenyl)-1-[2'-(N-2''-pyridinyl)-p-...

The effects of serotoninergic and noradrenergic drugs (applied intrathecally) on treadmill locomotion were evaluated in two adult cats subjected to a ventral and ventrolateral spinal lesion (T13). Despite the extensive spinal lesion, severely damaging important descending pathways such as the reticulo- and vestibulospinal tracts, both cats recovered quadrupedal voluntary locomotion. As detailed...

Islet hormone secretion is tightly regulated by metabolic status as well as local and circulating factors. These factors can activate different receptors on the pancreatic islet cells, for instance G-protein coupled receptors (GPCRs). When activated, these receptors are able to fine-tune islet hormone secretion and regulate overall β-cell function. Estrogen and serotonin are circulating factors...

For recent a decade, field of female sexual dysfunction for classification, it’s pathophysiology and treatment has been focused. However, the treatment of female sexual dysfunction especially many potential drugs, has been not approved by their government control since their safety or efficacy. Although these present states, many drugs for enhancing sexual desire or genital blood flow have been...

PURPOSE Chronic oxidative stress and subacute inflammation have been implicated as causes of age-related macular degeneration (AMD). In this study, we tested whether an orally available 5-OH-tryptamine (5HT) 1a receptor agonist, xaliproden, could protect against retinal pigment epithelium (RPE) cell damage in culture and in a mouse model of geographic atrophy. METHODS Paraquat was used to cre...

Autistic disorder is characterized by delay and deviance in the development of social interaction and communication as well as specific interests and repetitive restricted behaviors. Symptoms of the disorder are chronic and they are manifested before the age of 3 years. In addition to these symptoms, severe irritability such as aggression, tantrum, mood swings, and self-injury are sometimes see...

the brain. Several studies have indicated that the activation of the hypothalamic-pituitary-adrenal axis changes the serotonin (5-hydroxytryptamine, 5-HT) function in the brain. The 5-HT receptor subtypes, particularly 5-HT2A and 5-HT1A receptors, have been postulated to play an important role in the pathogenesis of depression. Some clinical studies have demonstrated increases in the number of ...

Diabetes and mental disorders are common chronic illnesses in the United States, affecting more than 16 million and 44.3 million Americans, respectively. As a result of the ever-increasing incidence of obesity, diabetes is being diagnosed more often, not only in the adult population but also in children. Additionally, more focus is being given to behavioral disorders in recent years, and the He...

Vortioxetine is an antidepressant that targets multiple pharmacologic modes of action at sites--or nodes--where serotonergic neurons connect to various brain circuits. These multimodal pharmacologic actions of vortioxetine lead to enhanced release of various neurotransmitters, including serotonin, at various nodes within neuronal networks.