نتایج جستجو برای: 52 high week
تعداد نتایج: 2230247 فیلتر نتایج به سال:
Estimating survival and documenting causes and timing of mortality events in neonate bighorn sheep (Ovis canadensis) improves understanding of population ecology and factors influencing recruitment. During 2010-2012, we captured and radiocollared 74 neonates in the Black Hills, South Dakota, of which 95% (70) died before 52 weeks of age. Pneumonia (36%) was the leading cause of mortality follow...
OBJECTIVE To compare the efficacy and safety between tocilizumab added to methotrexate and tocilizumab switched from methotrexate in patients with active rheumatoid arthritis (RA). METHODS This is a 2-year randomised, controlled study. RA patients with moderate or high disease activity despite methotrexate were randomly assigned either to tocilizumab added to methotrexate (add-on) or tocilizu...
Background: In recent years, the prevalence of obesity has reached epidemic proportions, and exercise is a powerful stimulus for decreasing obesity. The purpose of present study was to investigate the effects of High Intensity Interval Training (HIIT) on visceral and subcutaneous levels of Monocyte Chemo-attractant Protein-1 (MCP-1) in Wistar male Rats. Methods: Twenty male rats (8 week year...
This paper examines institutional and regulatory aspects of sustainable transport from a cross-national perspective. While institutions appear to play an important role in the economic success of many countries, it is not so clear that they also support sustainable development. A number of examples of the role of institutions in transport are discussed. Particular attention is focused among oth...
INTRODUCTION Demographic and disease characteristics may impact response to psoriasis therapies. The objective of this study is to explore the safety and efficacy profile of secukinumab in North American (NA) versus non-NA patients with moderate to severe psoriasis. METHODS Data were pooled from four phase 3 studies of secukinumab. Secukinumab (300 and 150 mg) was administered at baseline, we...
The aim of the present study was to determine the effect of treatment with omalizumab, an anti-immunoglobulin E antibody, on asthma-related quality of life (AQoL) in patients with moderate-to-severe allergic asthma. A total of 546 patients with allergic asthma were randomised to double-blind subcutaneous treatment with either placebo or omalizumab for 52 weeks. A constant beclomethasone dipropi...
13130 Background: The determination of optimal biological dose is critical to the successful development of antiangiogenic agents. Recent studies suggest that genetic heterogeneity of angiogenesis and interindividual variations in efficacy response to angiogenic inhibitors and their side effects exist. Imiquimod, approved to treat skin cancer, is a topical immune response modifier with antiangi...
Rationale: In the phase III, 52-week ETHOS (Efficacy and Safety of Triple Therapy in Obstructive Lung Disease) trial chronic obstructive pulmonary disease (COPD) (NCT02465567), triple therapy wi...
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