BACKGROUND Depressive disorder, including recurrent type (rDD), is accompanied by increased oxidative stress and activation of inflammatory pathways, which may induce DNA damage. This thesis is supported by the presence of increased levels of DNA damage in depressed patients. Such DNA damage is repaired by the base excision repair (BER) pathway. BER efficiency may be influenced by polymorphisms...

Many of the same inflammatory factors that promote tumor growth are also hypothesized to function as pain modulators. There is substantial interindividual variation in pain severity in cancer patients. Therefore, we evaluated 59 single nucleotide polymorphisms in 37 inflammation genes in newly diagnosed non-Hispanic Caucasian lung cancer patients (n = 667) and assessed their association with pa...

The present study was undertaken to investigate the effect of crude seed powder (CSP) and gross saponins extract (GSE) of seeds of Albizia lebbeck on antimicrobial activity by taking two Gram-positive (Staphylococcus aureus and Bacillus cereus), two Gram-negative (Escherichia coli and Salmonella Typhi) bacteria, and two fungi species (Aspergillus niger and Candida butyric) were taken at 25, 50,...

The properties of Na+-dependent L-alanine transport in human erythrocytes were investigated using K+ as the Na+ substitute. Initial rates of Na+-dependent L-alanine uptake (0.2mM extracellular amino acid) for erythrocytes from 22 donors ranged from 40 to 180pmol/litre of cells per h at 370C. Amino acid uptake over the concentration range 0.1-8mm was consistent with a single saturable component ...

We have designed and synthesized novel intercalating compounds that efficiently hydrolyze supercoiled plasmid DNA lacking depurine/depyrimidine sites. These intercalators consist of conjugates of diamine and thia-heterocyclic naphthalimide. Surprisingly, the initial hydrolyzed products comprised fragments with half the length of the original plasmid. We suggest a mechanochemical mechanism that ...

Madhuca longifolia is a traditional medicinal plant used in the treatment of several diseases including cancer in Indian system of medicine. Even though the chemical composition, bioactive principles and medicinal value of M. longifolia leaf have investigated earlier, the extraction of phytochemical compounds is not yet optimized, because preparation of extract will be of great importance as it...

Anthrax remains an important but relatively neglected disease of animals and humans. Its control in animals can be easily achieved by employing available vaccines. It is highly preventable in animals as well as humans. However, poverty, lack of information and appropriate medical support in the poor endemic areas of the world are some of the major obstacles in its control. We hypothesize that s...

Leszek A. Kleczkowski Plant Physiology Department, University of Urnea, 901-87 Urnea, Sweden Z. Naturforsch. 50c, 21-28 (1995); received October 21/November 21, 1994 Alternative Substrate, Cyanide, Cytosol, Glycolate Pathway, Glyoxylate Reductase Kinetic mechanism of purified spinach leaf NAD(P)H glyoxylate reductase (GR-1) was studied using either NADPH and NADH as alternative substrates with ...

In thermal characterization tests of bone cement according to the ASTM Standard Specification for Acrylic Bone Cement, time-temperature profiles of bone cement were observed to be sensitive to the thickness of the cement patty and the mold material. Due to the heat transfer from cement to the surrounding mold, such tests might underestimate the exothermic temperature of bone cement. Developing ...

A sol-gel derived ZnO-p-Si heterojunction structure were fabricated and investigated as a potential methane sensor. Three configurations with different contacts (Pd-Ag contact both on ZnO and Si / Pd-Ag on ZnO side and Au on Si / and Au on both sides of the junction) were fabricated in order to study the impact of the catalytic contact on the methane sensing properties. Structural characterizat...