Nedd4 is a member of a growing family of ubiquitin-protein ligases which consist of a lipid-binding domain, two to four WW domains and a C-terminal ubiquitin-protein ligase domain. The Nedd4 mRNA levels are developmentally regulated and Nedd4 protein is highly expressed in many mouse embryonic tissues. In this study we have used a far-Western screen to identify embryonic proteins that interact ...

To explore the role of oxytocin in the regulation of salt appetite and blood pressure, we conducted studies in oxytocin gene-knockout mice and determined (1) blood pressure and heart rate during day and night periods, (2) salt appetite after iso-osmotic volume depletion, and (3) salt appetite and blood pressure after central injection of angiotensin II. Long-term arterial catheters were inserte...

Large arteries from hypertensive subjects are hyperresponsiveness to 5-hydroxytryptamine (5-HT). We tested the hypothesis that small arteries (225 micro ID) have a profile similar to conduit arteries, including signal transduction mechanisms and the 5-HT receptor subtype(s) mediating arterial contraction in normal and high blood pressure. Aorta and mesenteric arteries from Sprague-Dawley (232+/...

Urban wastewaters (WW) are a major vector of many emerging pollutants (EPs) to aquatic ecosystems, as urban wastewater treatment plants (WWTPs) not designed abate them. New methods now critically necessary for more comprehensive analysis WW samples and the assessment WWTP efficiency in EP removal. To this end, present study aims develop methodology identify quantify EPs, especially pharmaceutic...

Salinity tolerance to Thai silver barb, Barbodes gonionotus was investigated under laboratory conditions using common salt (NaCl) and sea water. With a view to determine the median lethal concentrations (LC50 values), the fish were exposed to various concentrations of the salt and sea water for a period of 96. Common salt up to a concentration of 12 ppt and sea water up to a concentration of 10...

The variability of mercury (Hg) levels in Swedish freshwater fish during almost 50 years was assessed based on a compilation of 44 927 observations from 2881 waters. To obtain comparable values, individual Hg concentrations of fish from any species and of any size were normalized to correspond to a standard 1-kg pike [median: 0.69 mg kg⁻¹ wet weight (ww), mean ± SD: 0.84 ± 0.67 mg kg⁻¹ ww]. The...

The effects of salicylic acid (SA) on growth and metabolism of Brassica oleracea var. Capitata under salt stress was studied in a hydroponic culture. NaCl at 50 mM concentration and SA at 0.5, 1.0, and 1.5mM concentrations were used as treatments.  The results showed that salt exhibited inhibitory effects on shoot and root length, fresh and dry weight, and RWC of the seedlings. NaCl at 50 mM co...

We study the lepton-flavor-violating reaction μe → ee within two extensions of the standard model that include heavy neutrinos. The reaction is studied in the low energy limit in the form of muonium decay M → ee and in the high energy regime of a muon collider. The two theoretical models we consider are: model I, a typical see-saw model that violates lepton flavor and number by inclusion of ext...

Largemouth bass (Micropterus salmoides) and common carp (Cyprinus carpio) were collected from 13 sites located in the Mobile (MRB), Apalachicola-Flint-Chattahoochee (ARB), Savannah (SRB), and Pee Dee (PRB) River Basins to document spatial trends in accumulative chemical contaminants, health indicators, and reproductive biomarkers. Organochlorine residues, 2,3,7,8-tetrachlorodibenzo-p-dioxin-lik...