The combination effects of the well-known antiandrogenic fungicides, vinclozolin and procymidone, were tested both in vitro and in vivo. In vitro both vinclozolin and procymidone significantly inhibited the binding of agonist to the androgen receptor with the concentration that resulted in 50% inhibition (IC(50)) values of 0.1 and 0.6 micro M, respectively. By applying the isobole method, the e...

BACKGROUND AND AIM Curcumin at 100mg/kg has been shown to have a protective effect on crush nerve injury. However, it is unclear whether the protective effect of curcumin on nerve injury is dose dependent. The present study was designed to investigate such a possibility. METHODS The rats subjected to crush nerve injury were intraperitoneally administrated daily for 4 weeks with curcumin (50 m...

Objective: Previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for Rosa damascena (R. damascena). In the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of R. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (PTZ). Materials and Methods: The rats were divided to five groups: (1) Control...

objectives: mangifera indica (mango) is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. the present study evaluated the effects of commercial (vimang) and hydroalcoholic extract of mango on gentamicin-induced nephrotoxicity in rat. materials and methods: female wistar rats were treated w...

objectives: acute pancreatitis is an inflammatory condition of pancreas with sudden onset, high mortality rate and multiple organ failure characteristics. it has been shown that oxygen free radicals have an important role in development of pancreatitis and its complications. antioxidant, anti-inflammatory, anti-hepatotoxicity and gastroprotective properties of cichorium intybus l. suggest that ...

conclusions it seems that the preventive effects of rutin against damages caused by ida can be attributed to its ability to reduce apoptosis, which may be mediated by underexpression of caspase3 and overexpression of bcl2 genes. also, it could increase the expression of dazl that may be important in spermatogenesis. methods in the current experimental study, balb/c mice were divided into 8 grou...

This study investigates the cardioprotective activity of a combined treatment of Ginkgo biloba phytosomes (GBP) and Ocimum sanctum extract (Os) in isoproterenol (ISO)-induced myocardial necrosis in rats. Significant myocardial necrosis, depletion of the endogenous antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (...

We evaluated the anxiolytic and antidepressant effects of the aqueous extract of the bark of Tapinanthus dodoneifolius (TAE) (Danser) (25, 50, and 100 mg/kg), using open field, elevated plus maze, and forced swimming tests. Effect of TAE was compared to standard drugs diazepam (2 mg/kg) and imipramine (10 mg/kg). Additionally, the same doses of TAE were evaluated on rat's memory using Y-maze ta...