The 5' splice junction (5'SJ) of Group II intron transcripts is subject to a specific hydrolysis reaction (SJH). This reaction occurs either within a single transcript containing intron sequences through domain 5 (D5) or by cooperation of two separate transcripts, one bearing the 5'SJ and another contributing D5 (1). In this report we describe the latter reaction in terms of its kinetic paramet...

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Platinum rhodamine 123 [Pt(Rh-123)2] was synthesized in an effort to produce a new drug which would have the selective uptake into carcinoma cells of Rh-123 and the alkylating and radiosensitizing properties of the chloroplatinum moiety. Because both Rh-123 and cis-diamminedichloroplatinum(II) (CDDP) have been shown to become more cytotoxic at elevated temperatures, we tested the interactions b...

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We report the synthesis and evaluation of a series of iodinated celecoxib analogues as cyclooxygenase-2 (COX-2)-targeted single photon emission computerized tomography (SPECT) imaging agents for the detection of inflammation. The structure-activity relationship identified 5-(4-iodophenyl)-1-{4-(methylsulfonyl)phenyl}-3-(trifluoromethyl)-1H-pyrazole (8) as a promising compound with IC(50) values...

(123)I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of (123)I-MIBG in Lewy-body diseases including Parkinson's disease and dementia with Lewy bodies. Thus, cardiac MIBG uptake is now considered a biomarker of Lewy body diseases. Although sc...

Introduction. Let £ = (£ , p, B, F) denote a two stage Postnikov system with stable fe-invariant. We announce results about H*(ÜE) as a Hopf algebra over the Steenrod algebra. Mod 2 cohomology is used exclusively. Unexplained notation is from [4] and [S]. 1 am grateful to D. Anderson, W. Massey, F . Peterson and H. Salomonsen for many useful remarks. We make the following assumptions on £, in a...

The production of photons in hadronic collisions is quite interesting under two different aspects. Since the photon couples directly only to quarks, photon signals can be used to study the hard dynamics in a cleaner way with respect to processes where only hadrons are involved; the obvious drawback is that promptphoton cross sections are much smaller than say jet cross sections. Secondly, photo...