نتایج جستجو برای: 5 fluorophenyl 1

تعداد نتایج: 3371655  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2011
Cecilia Renzulli Mike Nash Mark Wright Steven Thomas Stefano Zamuner Mario Pellegatti Paolo Bettica Gary Boyle

N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-piperidinyl]methyl]-4-benzofurancarboxamide (SB-649868) is a novel orexin 1 and 2 receptor antagonist under development for insomnia treatment. The disposition of [(14)C]SB-649868 was determined in eight healthy male subjects using an open-label study design after a single oral dose of 30 mg. Blood, urine, and feces were collected...

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Analytical Sciences: X-ray Structure Analysis Online 2006

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Acta crystallographica. Section C, Structural chemistry 2016
William Raven Thomas Joschko Irmgard Kalf Ulli Englert

At the molecular level, the enantiomerically pure square-planar organoplatinum complex (SP-4-4)-(R)-[2-(1-aminoethyl)-5-fluorophenyl-κ(2)C(1),N][(R)-1-(4-fluorophenyl)ethylamine-κN](isocyanato-κN)platinum(II), [Pt(C8H9FN)(NCO)(C8H10FN)], and its congener without fluorine substituents on the aryl rings adopt the same structure within error. The similarities between the compounds extend to the mo...

2010
Cecilia Renzulli Mike Nash Mark Wright Steven Thomas Stefano Zamuner Mario Pellegatti Paolo Bettica Gary Boyle

N-[[(2S)-1-[[5-(4-fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2piperidinyl]methyl]-4-benzofurancarboxamide (SB-649868) is a novel orexin 1 and 2 receptor antagonist under development for insomnia treatment. The disposition of [C]SB-649868 was determined in eight healthy male subjects using an open-label study design after a single oral dose of 30 mg. Blood, urine, and feces were collected at f...

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