We have investigated the responsiveness to growth factors (GFs) of primary baby rat kidney (BRK) cells transformed by the E1 region of adenovirus 5 or 12. The in vitro growth of non-oncogenic adenovirus 5-transformed BRK cells is largely independent of serum GFs, whereas growth of highly oncogenic adenovirus 12-transformed cells is strictly dependent on GFs present in serum. For the growth of a...

Introduction: Neurosurgical planning of tumor resection seeks to minimize damage to healthy tissue during surgery. Diffusion tensor imaging (DTI) may help to resolve how the tumor has affected nearby white matter pathways, and to discriminate between fibers extending into the tumor, versus those deflected around it. Fiber orientation is usually modeled by the tensor principal eigenvector e1, en...

The bovine papillomavirus replication initiator protein E1 is an origin of replication (ori)-binding protein absolutely required for viral DNA replication. In the presence of the viral transcription factor E2, E1 binds to the ori and initiates DNA replication. To understand how the E1 initiator recognizes the ori and how E2 assists in this process, we have expressed and purified a 166-amino-aci...

class Value case class NumV(n: Int) extends Value case class BoolV(b: Boolean) extends Value (Technically, we could encode booleans as integers, but in general we will want to separate out the kinds of values.) Booleans and Conditionals Types Extending the interpreter // helpers def add(v1: Value, v2: Value): Value = (v1,v2) match { case (NumV(v1), NumV(v2)) => NumV (v1 + v2) } def mult(v1: Val...

(4) Consider the point y = (1/2, 0, 0) ∈ Ω. Is y an interior point of Ω? Characterize all the feasible directions e = (e1, e2, e3) ∈ R at y (a picture could help). Is y a (strict) local maximizer of f? (5) Consider the point z = (1/2, 1/2, 1/2) ∈ Ω. Is z an interior point of Ω? Characterize all the feasible directions e = (e1, e2, e3) ∈ R at z. Is z a (strict) local maximizer of f? What is the ...

Madin-Darby canine kidney (MDCK) cells can grow in synthetic medium supplemented with five factors--insulin, transferrin, prostaglandin E1, hydrocortisone, and triiodothyronine--as a serum substitute. These five factors permit growth for 1 month in the absence of serum and a growth rate equivalent to that observed in serum-supplemented medium. Dibutyryl adenosine 3',5'-cyclic monophosphate subs...

BACKGROUND A 16 week pregnant woman presented with massive theca-lutein cysts requiring bilateral oophorectomy. Pregnancy progressed uneventfully and spontaneous lactation ensued after delivery. METHODS To study the role of the ovary on the hormonal profile at the end of gestation and in post-partum, we measured FSH, estradiol (E2), unconjugated estrone (E1), unconjugated estriol (E3), sex ho...

The present study investigated the value of two repeated exposure interventions for increasing intakes of fruit in older people. A total of ninety-five participants (aged 65 years and over) were randomised to receive either one (E1), five (E5) or five plus (E5+) exposures to fruit over a 5-week period. Fruit exposures occurred in community-based church and social groups, through fruit-tasting s...

A graph G is triangularly connected if for every pair of edges e1, e2 ∈ E(G), G has a sequence of 3-cycles C1, C2, · · · , Cl such that e1 ∈ C1, e2 ∈ Cl and such that E(Ci) ∩ E(Ci+1) 6= ∅, (1 ≤ i ≤ l − 1). In this paper it is shown that every triangularly connected claw-free graph G with |E(G)| ≥ 3 is vertex pancyclic. This implies the former results in [2], [3], [4] and [5] that every connecte...

Deger C1, Ozdemir O2, Eldem B3, Unlu N4, Alp MN5, Saatci AO6, Ozmert E7, Altintas KA8, Sermet F7, Erdal E1, Sar C1, Asan S1, Sumer F1, Parali E1, Ozel O1 1 Bayer Turk Kimya San. Ltd. Sti., Istanbul, Turkey, 2 Yorum Consultancy Ltd., Istanbul, Turkey, 3 Hacettepe University Faculty of Medicine, Ankara, Turkey, 4 Ankara Training & Research Hospital, Ankara, Turkey, 5 Ankara Numune Training & Rese...