نتایج جستجو برای: 5α dihydrotestosterone
تعداد نتایج: 3573 فیلتر نتایج به سال:
Introduction: Seborrhea is a condition of sebaceous glands hyperactivity and increase in the secretion of sebum on head and face surface. Sebaceous glands hyperfunction causes oily and glassy appearance with large pores on the skin. The effect of androgens on providing seborrhea is controversial. Since sufficient and definite information about testosterone and dihydrotestosterone in seborrhic c...
Two new epoxy steroids, 5α,8α-epidioxy-22β,23β-epoxyergosta-6-en-3β-ol (1) and 5α,8α-epidioxy-22α,23α-epoxyergosta-6-en-3β-ol (2), and ten known steroids including (24R)-5α,8α-epidioxyergosta-6-en-3β-ol (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4), (22E,24R)-5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (5), β-sitosterol (6), sitost-5-en-3β-ol acetate (7), 7α-hydroxysitosterol (8), s...
Accepted: november 4, 2017 ABSTRACT Although more than three decades have passed since the first use of minoxidil in androgenetic alopecia (AgA), its mechanisms of action have still not been comprehensively understood. 5α-reductase (5α-r) has an active role as the predominant enzyme in both AgA and female pattern hair loss (fPHl), which are also the main therapeutic indications of topical minox...
The Rhodococcus erythropolis SQ1 kstD3 gene was cloned, heterologously expressed and biochemically characterized as a KSTD3 (3-keto-5α-steroid -dehydrogenase). Upstream of kstD3, an ORF (open reading frame) with similarity to 4 KSTD (3-keto-5α-steroid -dehydrogenase) was found, tentatively designated kst4D. Biochemical analysis revealed that the 1 KSTD3 has a clear preference for 3-ketosteroids...
BACKGROUND Benign prostatic hyperplasia (BPH) is non-cancerous condition of enlargement of the prostate, a common occurrence in older men. The immature fruits of Poncirus trifoliata (L.) Rafinesque (Rutaceae), Ponciri Fructus are widely used in traditional oriental medicine for the therapy of various diseases. However, little is known about the mechanism underlying the pathogenesis of BPH. In t...
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