In addition to these therapies, a new oral drug dutasteride has been reported to be efficient for AGA in a large-scale (n=917) randomized controlled trial (RCT) [2]. This reagent is a 5α-reductase inhibitor similarly to finasteride. Importantly, dutasteride suppresses both type I and II 5α-reductases while finasteride significantly suppresses only type II. Therefore, dutasteride is referred as ...

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania ...

Androgenic alopecia (AGA), scalp hair loss, occurs due to the hyperactivity of steroid 5α-reductase2 (SRD5A2), which metabolizes testosterone into 5α-dihydroxytestosterone. Finasteride, an FDA-approved drug producing many side effects, is a commonly used competitive inhibitor for SRD5A2 treat AGA. As number mushroom species have been patients having loss problems since ancient times, in present...

The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone indu...

inhibitor 3-methyladenine (3-MA) for 24 h, the apoptosis rate in AD condition dramatically increased to 7.18% ± 2.44% (P < 0.001), which could contribute to the volume shrinkage of the prostate effectively. Altogether, the results suggested the autophagy blockade might be a promising approach to reducing more prostate volume via apoptotic activity enhancement in prostatic epithelial cells. This...

The title compound, C(24)H(41)NO, is a new derivative of the anti-HIV steroid 17β-(N-tert-butyl-amino-carbon-yl)androst-4-en-3-one. There are four rings in the structure and these are trans-fused. The three six-membered rings exhibit chair conformations, while the five-membered ring adopts an envelope conformation.

We conducted the coincidence measurement of α particles inelastically scattered from 20Ne at 0° and decay charged in order to search for alpha-particle condensed state. compared measured excitation-energy spectrum branching ratio with statistical-decay-model calculations, found that newly observed states Ex=23.6, 21.8, 21.2 MeV are strongly coupled a candidate 4α state 16O. This result presents...