Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

Introduction: Colon adenocarcinoma is one of the foremost causes of cancer mortality. Oral metastasis of colon adenocarcinoma is, however, rare and indicates an end-stage disease process.   Case Report: We report a case of a 69-year-old female with a gingival mass diagnosed with colon adenocarcinoma and liver metastasis after one year. A swelli...

background of the study: colorectal cancer (crc) which is the third most diagnosed cancer throughout the world is steadily rising in the asian countries with the incidence rates mimicking the western counterparts. the pre-neoplastic nature of the transitional mucosa (tm) adjoining crc lacks conclusive evidence so far. pertaining to this, the study of the mucus layer, the functional component of...

cancer is one of the most fatal diseases in human beings which annually leads to death of 30000 individuals in iran. prevention, diagnosis and treatment of cancer is one of the major scientific challenges all around the world. it seems that increased incidence of several cancers such as colon and prostate and their mortality are connected with obesity. it is suggested that obesity and metabolic...

Obesity is linked to increased risk of colon cancer, currently the third most common cancer. Consequently rising levels of obesity worldwide are likely to significantly impact on obesityrelated colon cancers in the decades to come. Understanding the molecular mechanisms whereby obesity increases colon cancer risk is thus a focus for research to inform strategies to prevent the increasing trend ...

OSTEOPOROSIS FREQUENCY AND ITS RELATIONSHIP WITH SERUM LEVEL OF VITAMIN K2 IN COLON CANCER PATIENTS BEFORE AFTER COLECTOMY

microRNA (miRNA) dysregulation is frequently observed in colon cancer. Previous studies found that miR-223 is upregulated in colon cancer and functions as an oncogene. Conversely, p120 is often downregulated or even absent in colon cancer, and is a likely tumor suppressor. The present study showed that increased miR-223 and decreased p120 levels are associated with colon cancer malignancy, and ...

Colon cancer is one of the major causes of cancer mortality worldwide. However, the underlying mechanism and therapeutic targets of colon cancer have not yet been fully elucidated. In the present study, we demonstrate that citron rho-interacting, serine/threonine kinase 21 (CIT) promotes the growth of human colon cancer cells. CIT is overexpressed in human colon cancer tissues and cell lines. H...