Background: This study aimed to investigate Levisticum officinale hydroalcoholic extract (LOHE) effect on both cGMP signaling pathway and phosphodiesterase 5 (PDE5) gene expression pattern and to examine the role of LOHE in apoptosis induction of MCF-7 and MDA-MB-468 cell lines. Methods: The half maximal inhibitory concentration (IC50) of LOHE was examined in both cell lines using the MTT assay...

Appears in: ICERI2022 Proceedings Publication year: 2022Pages: 468-475ISBN: 978-84-09-45476-1ISSN: 2340-1095doi: 10.21125/iceri.2022.0152Conference name: 15th annual International Conference of Education, Research and InnovationDates: 7-9 November, 2022Location: Seville, Spain

background: understanding of cellular and molecular mechanisms involved in cell/tumor growth and progression has led to molecular-targeted therapy. her1 and her2 are two main oncogenic components of her-receptor family considered as targets for cancer research and therapy. reliable results of her- related research and targeted therapies dependent upon cell line with known her expression status....

Cetuximab resistance is the main obstacle for treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p upregulated in TNBC cells; thus, present study explored whether downregulation miR-155-5p enhanced anti-tumor effect cetuximab cells. MDA-MB-231 and MDA-MB-468 cells were infected with lentivirus-epidermal growth factor receptor (EGFR) 72...

This study was carried out to determine the responses of some new cotton (Gossypium hirsutum L.) lines Verticillium wilt disease (disease agent is Verticillum dahliae Kleb.) and enable use resistant or tolerant in future studies. The field trials were conducted at trial field, Dicle University, Diyarbakir, Turkey 2019. a naturally contaminated with V. dahliae. Nine advanced used as material. re...