AIMS Mutant protein aggregation (PA) cardiomyopathy (MPAC) is characterized by reductive stress (RS), PA (of chaperones and cytoskeletal components), and ventricular dysfunction in transgenic mice expressing human mutant CryAB (hmCryAB). Sustained activation of nuclear erythroid-2 like factor-2 (Nrf2) causes RS, which contributes to proteotoxic cardiac disease. The goals of this pre-clinical st...

Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrades damaged proteins in an ATP-independent manner. Exposure to very low, non-toxic, signaling conce...

The present investigation was undertaken with an objective to study the magnitude of heterosis involved in 32 hybrids obtained by crossing four (female) x eight (male) genotypes L T fashion along their 12 parents and two standard checks (JLT-408 PRACHI) evaluated during summer, 2019-20 at Oilseeds Research Station, Latur. Data were recorded on yield its different contributing traits. analysis v...

The gamma chain of human plasma fibrinogen is heterogeneous with three forms differing in length at the C-terminus. Alternative RNA splicing produces two gamma chain mRNAs encoding gamma 50 and gamma 57.5 polypeptides, while fibrinogen gamma 55 is produced by post-translational modification of the gamma 57.5 chain. The composition of purified variant gamma chain fibrinogens, which comprise 10% ...

INSUFFICIENT EVIDENCE TO DETERMINE EFFECTIVENESS OF THE INTERVENTION* Bans on Specified Firearms or Ammunition 406 Acquisition Restrictions 407 Waiting Periods for Firearm Acquisition 408 Firearm Registration and Licensing of Firearm Owners 410 Shall Issue Concealed Weapons Carry Laws 411 Child Access Prevention (CAP) Laws 413 Zero Tolerance of Firearms in Schools 414 Combinations of Firearms L...