BACKGROUND Usual treatment regimens with vancomycin often fail to provide adequate serum levels in patients with severe infections. METHODS Retrospective analysis of vancomycin trough serum measurements. The following parameters were calculated by Bayesian analysis: vancomycin clearance, distribution volume, and peak estimated concentrations. The area under the concentration curve (AUC) (tota...

a good deal ahead of the older parts of the building. From the beginning of the Hospital, some sixty years ago, it has been in the hands of the Sisters of the Community of the Holy Bood, whose capacity has made it to-day one of the two big general hospitals of Middlesbrough and a recognised training school for nurses, with, including the new wards, 176 beds. The Sisters are helped in the manage...

OBJECTIVES The atypical antipsychotic quetiapine is a first-line treatment for schizophrenia. This non-interventional study (NCT01212575) evaluated the clinical use of its two formulations, extended release (XR) and immediate release (IR), in outpatients with schizophrenia spectrum disorder. METHODS Patients who had received at least one dose of quetiapine XR and/or IR were included. A dosage...

A hug is a wholesome thing. At least at one time it was. Most people considered a hug genial and benevolent. It conveyed a positive meaning: a praise, an expression of encouragement, or consolation. A hug meant someone was being friendly. Those were the days before sexual harassment issues and sexual assault cases. Now a hug often is suspect. The motivation for touch frequently is questioned. T...

Software architecture is the key factor for efficient communication, planning, development, maintenance, and hence, the overall success of the development project. Architecting is an upfront investment made by development organizations to assure that the resulting system(s) will meet the required quality criteria in time and effort. Among others, the software architecture captures the envisione...

The height/radius ratio of a tumulus and the angle of repose for the materials used in its construction permits one to: predict possible construction methods, calculate the path of geometric evolution before and after the current form and compare degrees of preservation. By way of example a Neolithic tumulus is compared with a modern-day one, both made out of identical lithology. Finally, comme...

The Venus of Dolní Věstonice I (Gravettian, 25, 000 B.P.) was discovered on July 13th, 1925 in Dolní Věstonice, South Moravia (Czechoslovakia), during Moravian Museum excavations. The figurine, made from fired clay, about 11.5 cm high, represents a woman with a plump figure. More than 75 years after its discovery, a fingerprint on the left side of the figurine back was analyzed. The dimensions ...