Tetrahydroaminoacridine (THA) is a centrally active anticholinesterase that also interacts with neuronal K+ and Na+ channels and cardiac Ca2+ channels. The effects of THA on neuronal voltage-dependent Ca2+ channels are not known. We tested the effects of THA (25 nM-250 microM) on the Ca2+ current components of acutely dissociated rat nodose ganglion and dorsal root ganglion (DRG) neurons using ...

subchondral insufficiency fracture of the femoral head (siffh) is characterized by acute onset hip pain without overt trauma. it appears as a low intensity band with bone marrow edema on t1-weighted mri. the most common course of treatment is protected weight bearing for a period of several weeks. total hip arthroplasty (tha) has been commonly used if the patient does not respond to the initial...

BACKGROUND Both minimally invasive surgery (MIS) and computer-assisted surgery (CAS) for total hip arthroplasty (THA) have gained popularity in recent years. We conducted a qualitative and systematic review to assess the effectiveness of MIS, CAS and computer-assisted MIS for THA. METHODS An extensive computerised literature search of PubMed, Medline, Embase and OVIDSP was conducted. Both ran...

OBJECTIVE To assess the efficacy of a single intra-articular injection of triamcinolone hexacetonide (THA) in knee osteoarthritis (OA) and examine factors which may relate to treatment efficacy. METHODS Eighty four patients with clinical and radiographic evidence of knee OA were recruited and randomly allocated to receive either THA (20 mg in 1 ml) or placebo (0.9% normal saline, 1 ml). Follo...

BACKGROUND Rates of hip arthroscopy have been on an exponential rise. The purpose of this study was to evaluate the rate and timing of subsequent total hip arthroplasty (THA) after hip arthroscopy and identify if rates of THA differed based on age, diagnosis of osteoarthritis, or arthroscopic procedure performed. METHODS The Humana administrative claims data set was reviewed from 2007 to 2014...

BACKGROUND Natural products represent an important source for agents of cancer prevention and cancer treatment. More than 60% of conventional anticancer drugs are derived from natural sources, particularly from plant-derived materials. In this study, 2α, 3α, 19β, 23β-tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid from the leaves of Sinojackia sarcocarpa, was isolated, and its ant...

A field experiment was conducted at the Agriculture Research Farm, Bhagwant University, Ajmer, Rajasthan, India, during rabi seasons of 2020-21 and 2021-22. There were Ten treatments imposed in chickpea viz., T1- Control, T2- Farmers practice (50 kg DAP ha-1), T3- RDF, T4- FYM @ 10 tha-1, T-5 Vermicompost @5 T6- RDF + 5 T7- T8- 75% FYM@ 2.5 tha-1 1.0 T9- 50% T10- 25% 5.0 tha-1. These evaluated ...

Mục tiêu: Khảo sát các chỉ số sinh lý cùng một yếu tố liên quan ở 2 nhóm bệnh nhân tăng huyết áp nguyên phát và không áp. Đối tượng phương pháp nghiên cứu: Mô tả, tiến cứu, có đối chứng trên 236 được chẩn đoán xác định THA 196 mắc đến điều trị ngoại trú tại Bệnh viện Đa khoa thành phố Vinh, tỉnh Nghệ An từ ngày 01/01/2022 đến 30/5/2022. Kết quả: Nhóm thì độ tuổi ≥ 65 chiếm nhiều nhất (55,1%), n...

Tranexamic acid (TXA) reduces red blood cell transfusion in various orthopedic surgeries, yet the degree of practice variation its use among anesthesiologists and surgeons has not been described. To target future knowledge transfer implementation strategies, to better understand determinants variability prophylactic TXA use, our primary objective was evaluate influence surgical team members on ...

BACKGROUND To address the long-term problems of bearing surface wear and osteolysis associated with conventional metal-polyethylene (M-PE) total hip arthroplasty (THA), metal-metal (M-M), and ceramic-ceramic (C-C) bearings have been introduced. These bearing surfaces are associated with unique risks and benefits and higher costs. However the relative risks of these three bearings in an older po...