introduction: although the synergistic effects of opioids and other analgesic drugs such as non-steroidal anti-inflammatory drugs (nsaids) have been established in relieving acute pain due to renal calculi, no studies today have evaluated the concomitant administration of opiates and other drugs with analgesic effects, such as serotonin re-uptake inhibitors. considering the high prevalence of r...

UNLABELLED Very small doses of intrathecal (i.t.) morphine (25-200 microg) have been used in an effort to provide effective postoperative pain relief while minimizing side effects after cesarean delivery. We performed a double-blinded study in 40 patients presenting for elective cesarean delivery in which i.t. morphine was administered along with oral hydrocodone/acetaminophen and other medicat...

Introduction: Nowadays Opioids are gaining acceptance for the management of moderate to severe and chronic pain. In addition, a number of studies have shown that plasma levels of β-endorphin (βEP) in exercise trained are higher than sedentary rats. In our study we assume that exercise training can reduce pain after withdrawal syndrome in morphine-dependent rats. Methods: Male Wistar rats (2...

introduction: today nano-medicine tries to produce new drugs to reduce the dosage and side effects of their conventional forms. according to the interaction between zinc and opioidergic system activity, this study has investigated the effect of new kind of zinc supplement, nano zinc oxide (nzno), in compared to its conventional form (czno), in presence and absence of opioidergic system activity...

AIM Combined analgesic regimens produce sufficient analgesia by additive or synergistic effects, and reduce the total dose of analgesics and minimise adverse effects. We investigated the metamizole, paracetamol and morphine combination with respect to postoperative pain treatment in lumbar disc surgery. MATERIAL AND METHODS After Ethics Committee approval and informed consent, 63 patients wer...

conclusions in this study, intravenous paracetamol or diclofenac suppositories, administered for postgastrectomy pain control, decreased morphine consumption by almost 32% and also improved alertness. nevertheless, the amount of opioids did not affect the incidence of complications. background major surgical procedures, such as gastrectomy, result in extensive postoperative pain, which can lead...

it has been shown that stress and chronic pain could prevent the development of tolerance to morphine analgesia, which appears to be related to the activation of hypothalamus–pitutitary–adrenal (hpa) axis, activation of neuroendocrine systems and changes in neurochemical levels. moreover, the involvement of nitric oxide (no) in the development of tolerance to morphine analgesia has been implica...