this review deals with studies that have used cdna microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. the key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. it concludes that “basal-like” carcinomas d...

INTRODUCTION The basal dose of insulin, proportion of total daily insulin, and circadian variation during continuous subcutaneous insulin infusion (CSII) therapy among children with type 1 diabetes mellitus (T1D) have not been fully elucidated. MATERIALS AND METHODS A total of 45 childhood patients with T1D receiving CSII therapy at Pediatrics Department of Chang Gung Memorial Hospital betwee...

We present a nonlinear random-effects stochastic differential equation (SDE) model of combined basal and pulsatile hormone secretion with a series-specific hormone half-life and conditional pulse times. The construct uses a three-parameter pulse shape (generalized gamma function) to allow variably skewed secretory bursts superimposed on a finite basal hormone secretion rate. The analysis imbeds...

The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some reduction in basal blood pressure but pressor response to A II was not changed. Treatment for 20 da...

Aspergillus nidulans hyphae have long tip cells that are separated from short basal cells by septa. Basal cells average 40 microm long with three or four nuclei. Septation follows parasynchronous mitoses in the tip cell and seems to occur at premarked sites, but how these sites are established is unclear. A. nidulans strains with the hypA1 mutation are wildtype at 28 degrees C but if shifted to...

BACKGROUND The spectrum of post-streptococcal brain disorders includes chorea, tics, and dystonia. The proposed mediators of disease are anti-basal ganglia (neuronal) antibodies (ABGA). AIM To evaluate ABGA as a potential diagnostic marker in a cohort of UK post-streptococcal movement disorders. METHODS Forty UK children presenting with movement disorders associated with streptococcal infec...

A large population of immature neurons is present in the ventromedial portion of the adult primate amygdala, a region that receives substantial direct projections from the hippocampal formation. Here, we show the effects of neonatal (n = 8) and adult (n = 6) hippocampal lesions on the populations of mature and immature neurons in the paralaminar, lateral, and basal nuclei of the adult monkey am...

In this study, the effects of boric acid and humate supplementation into hen diets on egg production and quality parameters and blood cholesterol levels were examined. For this aim, totally 160, 40 weeks of age, Hyline-White 98 layers were randomly divided into control and 3 treatment groups each containing 40 birds and 10 replicates (each with 4 birds). There was no boric acid or humate supple...

background: to glean insights into the relationship among hepatitis b virus (hbv) genotype/subgenotypes, a1762t/g1764a mutations and advanced liver disease such as liver cirrhosis (lc) and hepatocellular carcinoma (hcc) in southeast china. methods: a case-control study was performed, consisting of chronic hepatitis b (chb) patients (n=160), lc patients (n=150), and hcc patients (n=156). fluores...