During the synthesis of functionalized energetic triazole derivatives for biosensor detection devices 1 carboxymethyl 3 diazonio 5 nitrimino 1,2,4 triazole (2) was obtained by nitration of sodium 1 carboxymethyl 3,5 diamino 1,2,4 triazole (1). Zwitterionic (2) behaves like a diazonium cation which was proved from its reaction with sodium azide by the formation of 3 azido 5 nitrimino 1,2,4 triaz...

The development of effective and safe therapeutic agents using 1,2,4-triazole derivatives is gaining momentum in today’s conditions. value such drugs determined by the rapid prolonged biological action, which not accompanied abrupt changes homeostasis pronounced side effects, are characteristic most pharmacological synthetic origin. In context a limited range domestic antimicrobial antifungal v...

Due to the limited number of drugs in current clinical use, diverse biological applications furan have encouraged preparation a wide variety thiosemicarbazide and triazole derivatives for purpose developing new drug agents. This study aimed investigate antiproliferative antioxidant activities thiosemicarbazides (1–12) 1,2,4-triazoles (13–24). Out synthesized target compounds, 3, 4, 6, 7, 8, 9, ...

The new regioisomer derivatives 4a-f and 5a-f of 3-nitro-1,2,4-triazole (3-NTR) were synthesized for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy. N(2)-Substituted 3-NTR derivatives 5a-f were stronger radiosensitizers of hypoxic cells in vitro (Chinese hamster V79 cells) than N(1)-substituted 3-NTR derivatives 4a-f, but in vivo they were weaker (SCCVII carcin...

The study investigated the corrosion-inhibitory properties of three synthetic triazole Mannich bases on C1018 carbon steel using various electrochemical techniques. inhibitors, namely 4-amino-2-[(4-methylpiperazin-1-yl)methyl]-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (4MPT), 4-amino-2-[(piperidin-1-yl)methyl]-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (PPT) and 4-ami...

The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1,2,4-triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2,3,4) in an alkaline solution, is reported. Also, the S-alkylation of triazole derivatives 5-7a-c is described. The structure of the syn...

Triazoles with different substituent groups are found to possess diverse applications in the field of medicine and industry. A series of 4-(substituted ethanoyl)amino-3-mercapto-5-(4-nitro)phenyl-1,2,4-triazoles (NU-1 to NU-15) were synthesized as novel antimicrobial agents starting from 4-nitrobenzoic acid. The chemical structures of these newly synthesized compounds were elucidated by IR, 1H ...

A kind of spin crossover-macromolecule polymer composite material, [Fe(NH(2)trz)(3)(ClO(4))(2)]-PVP (NH(2)trz is 4-amino-1,2,4-triazole and PVP is polyvinylpyrrolidone), appears as homogeneous film with a regular structure in nano-scale and shows the spin crossover (SC) phenomenon.

The new ligands, 1-(4-isopropyl phenyl)-4-(2-pyridyl)-1,2,3-triazole, 1 and 1-(mesityl)-4-(2-pyridyl)-1,2,3-triazole, 2 were prepared by the reactions of the respective azides with 2-ethynylpyridine following the "click method". These ligands together with the reported ligands 1-(phenyl)-4-(2-pyridyl)-1,2,3-triazole, 3 and 1-(benzyl)-4-(2-pyridyl)-1,2,3-triazole, 4 were reacted with palladium a...