s: Alkylphenolpolyethoxylates (APEs) are used as non-ionic surfactants and antioxidants in detergents, herbicides, pesticides, paints and plasticware. In this study, it was sought to determine the effects of nonylphenol (NP), a derivative of (APEs), on growth, feed conversion ratio, egg production, and hatching in quails. Quails were exposed to 0 (control), 10, 100, 500, 1000 and 5000 μg NP/kg ...

The adult rat brain develops through an interplay of neuronal proliferation and programmed cell death. Steroid hormones and growth factors may alter the balance between these competing processes. "Endocrine disrupters" (EDs) may also alter brain development, by mimicry or modulation of endogenous hormone systems. Under control conditions, the sexually dimorphic nucleus (SDN) of the medial preop...

The response of male Fundulus heteroclitus to estrogenic compounds was assessed in anticipation of using this species in endocrine disrupter field studies in the Chesapeake Bay. Measurements of plasma vitellogenin, gonadosomatic (GSI) and hepatosomatic (HSI) indices, and an assessment of changes in gonadal histology were made. Of the parameters assessed, vitellogenin was found to be the most se...

The metabolism of 14C-4-n-nonylphenol (l4C-4-n-NP), as a model for the xenoestrogen nonylphenol, was investigated in three types of tobacco cell suspension cultures: one genetically non-modified culture (NT) and two cultures constitutively expressing human cytochrome P450 CYP1A1 or CYP1A2. With 1 mg l(-1) of 14C-4-n-NP and 24 h of incubation, the xenobiotic was transformed almost completely to ...

This paper reports the reconstruction of the pollution history of 4-tert-octylphenol (OP) and 4-nonylphenol (NP) in the Baltic Sea. Alkylphenols are endocrine-disrupting compound and therefore toxic to aquatic organisms. Sediment cores were collected from regions with relatively stable sedimentation conditions. The cores were dated by the (210)Pb method. The OP and NP were determined using HPLC...

We investigated the regulation of the muscarinic cholinergic receptor (MChR) in brain from seven species of fish, two surrogates and five threatened or endangered species exposed to a series of chemicals as a measure of compensatory response among species. Fish were classified as either cold water (rainbow trout-surrogate, apache trout, lahanton trout) or warm water (fathead minnow-surrogate, r...

introduction: in this study, the effect of para-nonylphenol as an environmental pollutant on viability, morphology and proliferation of bone marrow mesenchymal stem cells was investigated. methods: bone marrow mesenchymal stem cells of rat were treated with the 0.5, 1, 2.5, 3.5 and 5 μm of paranonylphenol for a period of 21 days, then the viability of the cells were estimated using trypan blue ...