reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methyl-imi...

were isolated from the roots of Verbascum lasianthum Boiss. ex Bentham. In addition, 2 phenylethanoid glycosides, verbascoside {=acteoside, [β-(3,4-dihydroxyphenyl)-ethyl]-(3′-O-α-L-rhamnopyranosyl)-(4′ O-caffeoyl)-β-D-glucopyranoside} (4) and poliumoside {= [β-(3,4-dihydroxyphenyl)-ethyl]-(3′,6′-O-αL-dirhamnopyranosyl)-(4′ -O-caffeoyl)-β-D-glucopyranoside} (5), were also isolated. The structur...

Two new secondary metabolites, the phenylpropanoid 3-(2',4',5'-trimethoxyphenyl)propanoic acid (1) and the sesquiterpene (+)-1beta,4beta,6alpha-trihydroxyeudesmane (2) were isolated from the heartwood of Cordia trichotoma Vell., along with the known sesquiterpenes (-)-1beta,4beta,7alpha-trihydroxyeudesmane (3) and (+)-1beta,4beta,11-trihydroxyoppositane (4). Their structures were elucidated by ...

The reaction of P-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3). The reaction of diketones (1) with urea in the presence of p-toluenesulfonic acid gave 4-(or 6-)aryl-6-(or 4-)(1-methyl- 5-nitro-2-imidazolyl)-1-(lH)pyrimidones (4). The structures of all compounds w...

A series of coumarin Schiff bases (7-(arylidenehydrazinocarbonylmethoxy)-2-oxo-2H-chromen-4-yl]acetic acid arylidenehydrazide) (4a-k) and N-(2-aryl-4-oxothiazolidin-3-yl)-2-{[4-(2-aryl-4-oxothiazolidin-3-yl)carbamoylmethyl]-2-oxo2H-chromen-7-yloxy}-acetamides (5a-k) were synthesized and evaluated for their antioxidant activity (scavenging of 1,1diphenyl-2-picryhydrazyl radical and phosphomolybd...

While inflammatory cytokines are well-recognized critical factors for the induction of cyclooxygenase-2 (COX-2) in activated fibroblast-like synovial cells, the roles of biologically active components other than inflammatory cytokines in synovial fluid remain unknown. Herein, we assessed the role of lysophosphatidic acid (LPA), a pleiotropic lipid mediator, in COX-2 induction using synovial flu...

Novel isoxazolopyridone derivatives that are metabotropic glutamate receptor (mGluR) 7 antagonists were discovered and pharmacologically characterized. 5-Methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one (MDIP) was identified by random screening, and 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) was produced by chemical modification of MDIP. MDIP and MM...