To define the influence of weight loss on the severity of metabolic abnormalities in patients with the same stage and primary site of cancer, hepatic glucose production (HGP) and nutritional status were determined in 44 patients with advanced. Stage D coloréela! carcinoma and compared to values in seven cancer-free controls. The colorectal cancer patients were divided into three groups based u...

It is well known that the fate of transplanted tumors is controlled by the genetic relationship be tween the host and the tumor used for transplanta tion. This c@ncept has been accepted since the work of Little, Strong, Bittner, and others, as it has been reviewed by Bittner (1, 2), Little (5), Gorer (4), and Snell (9). In a study of some aspects of the growth of spontaneous and transplanted ma...

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Lung cancer was induced in rabbits by the instillation of chemical carcinogens into the lower bronchus, with the use of a bronchoscope. The rabbits were divided into 2 groups. Group 1 received a mixture of 3-methylcholanthrene (3-MCA) and 4-nitroquinoline 1-oxide in rabbit plasma, and Group 2 received 3-MCA alone in distilled water. Doses of 40 mg of 3-MCA and 0.4 mg of 4-nitroquinoline 1-oxide...

Treatment of the 5′-carboxaldehyde derived by Moffatt oxidation of 6-N-benzoyl-2′,3′-Oisopropylideneadenosine (1) with the “(bromofluoromethylene)triphenylphosphorane” reagent and deprotection gave 9-(6-bromo-5,6-dideoxy-6-fluoro-â-D-ribo-hex-5-enofuranosyl)adenine (4). Parallel treatment with a “dibromomethylene Wittig reagent” and deprotection gave 9-(6,6dibromo-5,6-dideoxy-â-D-ribo-hex-5-eno...

controversial because of their obscure mechanisms. A randomized crossover study, using iron lung and positive pressure nasal ventilation (BiPAP) each for 40 mm, was performed in 11 stable patients with severe COPD. Throughout the study, we monitored surface EMGdi, EMGst, ECG, Sa05, ETCO2, and the movements of RC and tB. Afterwards the data were replayed to calculate VT, RR, PR, VT/TI, iEMG, and...

in vitro (3). After the carrier state has ended (about 40 days after infection) and resistance to tumor challenge has declined, the latter can be †̃ †̃recalled' â€b̃y injection of i i RX protein antigen at the site of tumor challenge (4, 6). Activated macrophages have been suggested (e.g. , Ref. i) to have a function in immune surveillance against neoplasia. Since S. enteritidis combines the p...

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The “glass transition problem,” which refers to the spectacular change in dynamic properties of liquids cooled towards their glass transition, remains unsolved. The difficulty is that there are many properties associated with vitrification of a liquid, and these have interrelationships which complicate any analysis. Recently attention has been directed at the spatial heterogeneity of the dynami...