BACKGROUND This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue. METHODS Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals...

OBJECTIVE This study was carried out to investigate the influence of pulsed-wave low-level laser therapy (LLLT) on the healing of a deep second-degree burn model in rat. BACKGROUND DATA Review of literature indicates that LLLT has a biostimulatory effect on wound healing; however, no clear recommendation can yet be made. METHODS Two deep second-degree burns were made in the skin of 67 rats....

Emerging bacterial resistance renders many antibiotics ineffective, making alternative strategies of wound disinfection important. Here the authors report on a new, physical burn wound disinfection method: pulsed electric fields (PEFs). High voltage, short PEFs create nonthermal, permanent damage to cell membranes, possibly by irreversible electroporation. In medicine, PEF technology has recent...

BACKGROUND Patients with burns are susceptible to organ failure, and there is indirect evidence that leukocytes may contribute to this process. They may change the expression of cell-surface receptors after certain stimuli, for example, the burn. We therefore aimed to assess the changes induced by the burn in the expression of leukocyte cell-surface receptors CD11b, CD14, CD16, and CD62L on the...

Surgical intervention of second degree burns is often delayed because of the difficulty in visual diagnosis, which increases the risk of scarring and infection. Non-invasive metrics have shown promise in accurately assessing burn depth. Here, we examine the use of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) for predicting burn depth. Contact burn wounds of increasing...

4,547 burn patients from 1983-1993 were reviewed by analysing the general data, mortality, and the causes of the death, and the mortality of 606 burn patients in different periods from 1958 to 1993. The purpose was to present some statistical and epidemiological data. The results showed: The incidence of burn injury in children, whose ages were less than 5 years, reached 36.2%, and the causes o...

BACKGROUND Advances in the care of burn injuries have resulted from the efforts of regional patient-based specialist teams at burn care centers. OBJECTIVES We conducted this study to assess the four-year epidemiology of burn injuries in Rasht, Iran. MATERIALS AND METHODS In this cross-sectional study, medical records of 2274 burn patients, treated at Velayat hospital from January 2007 to De...

The aim of this study was ultrasound evaluation of atherosclerotic plaque morphology in relation to the degree of coronary artery lumen narrowing in patients with ischaemic heart disease. Intravascular ultrasound was performed on 38 patients (30 men and 8 women) aged 35 to 77 (average age 60 +/- 11 years old) with symptoms of ischaemic heart disease. The structure of atherosclerotic plaques wit...

Minoxidil has been reported to inhibit in-vitro fibroblast proliferation and lysyl hydroxylase activity, a key enzyme in collagen biosynthesis. These in-vitro effects proposed minoxidil to be a potential antifibrotic agent. The present study aimed to investigate the effects of minoxidil gel on wound healing procedure in a second-degree burn model in rats. Wistar rats were anesthetized and a sec...