RAS and BRAF genes are crucial therapeutic prognostic markers in metastatic colorectal cancer. Once activated, these oncogenes play a key role carcinogenesis from the beginning steps until metastasis development. Several hotspot mutations were described KRAS NRAS codon 600 of gene. Herein, we interested RAS/BRAF mutation profiles cancer compared to non-metastatic tumors. We screened for byt he ...

Langues en contexte, Ali Reguigui, Julie Boissonneault, Leila Messaoudi, Hafida El Amrani et Hanane Bendahmane (dir.), Sudbury, Série monographique sciences humaines, no 22, 2019, 394 p.. Un article de la revue Nouvelles perspectives sociales (Sur le thème : les interpellées par question reconnaissance au travail) diffusée plateforme Érudit.

We report the isolation and characterization of a chicken cDNA which putatively encodes an actin-like protein (chACTL). This 394-amino-acid (aa) polypeptide shares sequence homology (81, 70 and 67% identical aa, respectively) with three actin-related proteins (ARP) described for Drosophila melanogaster (ARP14D), Caenorhabditis elegans (ACTL) and Saccharomyces cerevisiae (ACT2). At least six chA...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 5.8 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 260 6.7 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 8.1 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 300 7.8 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

Design: By using the Kaplan-Meier life-table method, we compared disease progression (measured as time to a 20-point increase in the Appel ALS score) and survival in 1041 patients diagnosed as having ALS between January 1, 1984, and January 1, 1999 (historical group, n=647), and between January 2, 1999, and November 1, 2004 (contemporary group, n=394). The Cox proportional hazards model was use...