نتایج جستجو برای: 35 mt3d pmwin
تعداد نتایج: 179713 فیلتر نتایج به سال:
This review is prompted by recent findings that the perirhinal and parahippocampal cortices in the monkey brain are important components of the medial temporal lobe memory system. Given the potential importance of the comparable rcgions 1 0 niemory function in rhe rat brain, it is surprising that so little is known about their neuroanatomy. In fact, there are no comprehensive studies of the bor...
The present study utilized event-related fMRI to address the role of the human perirhinal cortex (PRC), and its interactions with the hippocampus, in memory consolidation. Participants encoded object-based and scene-based associations and then restudied them either after a "long" or "short" delay during which consolidation could occur. We found that BOLD activation in left PRC and hippocampal-P...
It is widely believed that declarative memory is mediated by a medial temporal lobe memory system consisting of several distinct structures, including the hippocampus and perirhinal cortex. The strong version of this view assumes a high degree of functional homogeneity and serial organization within the medial temporal lobe, such that double dissociations between individual structures should no...
Two groups of rats were shown individual novel visual objects. One group had been familiarised to the environmental context within which the objects were shown, the other experienced the situation for the first time. The activation of neurones in perirhinal cortex and the hippocampal formation was determined by counts of nuclei stained for products of the immediate early gene c-fos. The ratio o...
Critical to perceiving an object is the ability to bind its constituent features into a cohesive representation, yet the manner by which the visual system integrates object features to yield a unified percept remains unknown. Here, we present a novel application of multivoxel pattern analysis of neuroimaging data that allows a direct investigation of whether neural representations integrate obj...
Rats with perirhinal cortex lesions were sequentially trained in a rectangular water tank on a series of 3 visual discriminations, each between mirror-imaged stimuli. When these same discriminations were tested concurrently, the rats were forced to use a configural strategy to solve the problems effectively. There was no evidence that lesions of the perirhinal cortex disrupted the ability to le...
The perirhinal cortex and hippocampus have close anatomical links and it has, therefore, been proposed that they have important, coordinated roles in memory. This review examines the relative role of these structures in spatial memory tasks that are known to be hippocampal-dependent. The published lesion data gives a mixed picture, as only some studies detect spatial deficits after perirhinal c...
Damage to the perirhinal cortex (PRh) in rats impairs anterograde object-recognition memory after retention intervals of up to several hours, but there is little direct evidence to link PRh function to object-recognition abilities after substantially longer intervals that span several days or weeks. We assessed the effects of PRh lesions on anterograde object recognition using a novel-object pr...
The role of the postrhinal cortex (POR) and the perirhinal cortex (PER) in processing relational or contextual information was examined with Pavlovian fear conditioning. Rats with electrolytic or neurotoxic lesions of the POR or PER were tested in 2 contextual fear conditioning paradigms. In Experiment 1, electrolytic lesions of the POR or PER produced impairments in contextual fear conditionin...
In the delayed match-to-sample task, responses of inferior temporal neurons to adjacent stimuli in the sequence are correlated to each other when the monkey was trained repeatedly with the sequence of visual stimuli, although the monkey was not required to associate the stimuli with each other. This correlation, however, is not observed for a monkey with lesions of the rhinal cortex, which is n...
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