Purpose: To investigate the effect of miR-339 on neuropathic pain.
 Methods: A rat pain model was established through chronic constriction injury (CCI). Expression in spinal cord determined 14 days later. Microglial inflammatory response evaluated using immunofluorescence analysis ionized calcium binding adaptor molecule 1 (Iba1), while IL-6 and TNF-α were assessed by enzyme-linked ...

INTRODUCTION Arthritis induced by immunisation with glucose-6-phosphate isomerase (GPI) in DBA/1 mice was proven to be T helper (Th) 17 dependent. We undertook this study to identify GPI-specific T cell epitopes in DBA/1 mice (H-2q) and investigate the mechanisms of arthritis generation. METHODS For epitope mapping, the binding motif of the major histocompatibility complex (MHC) class II (I-A...

Based on the distinction between expressive and instrumental motives, six theoretical mechanisms for the formation of trust relationships are elaborated and empirically tested. When expressive motives drive tie formation, individuals primarily attach emotional value to social relationships. Three mechanisms have been tested: the homophily, the balancing, and the gossiping effect. When instrumen...

Humoral alloimmunization to red blood cell (RBC) antigens is a clinically significant problem that can lead to transfusion reactions and difficulty in locating future compatible blood for transfusion. However, factors regulating responder/nonresponder status are only partially understood. Herein, we identify a series of microbes with 100% identity in 8- to 9-amino acid peptides containing the v...

In this study, we identified a c-erbB-2/HER2/neu (HER2)-derived Th epitope (HER216-30) and examined the role of Th epitopes in HER2-specific CD8+ T cell induction and in vivo tumor eradication, with a particular emphasis on the role of tumor cell-derived Th epitopes. Immunization of BALB/c mice using a mixture of Th epitope HER216-30 and CTL epitope HER263-71 administered subcutaneously with mu...

Yûnus Emre, hümanizm felsefesinin tartışılmaz önderlerinden biri olarak Türk dili, tarihi ve edebiyatında önemli bir yere sahiptir. Şiirlerinin hem içerik de sanatsal değeri çok sevilmesine yol açmıştır. Bu nedenle eserlerinin pek nüshası bulunmaktadır.
 çalışmada Yunus Emre Dîvânı’nda geçen dört büyük melekten olan İsrâfil’in Kıyamet Günü’nde üfleyeceği boru Sûr ile birlikte kullanılan ya...

إن العلاقات الليبية الأوروبية علاقات موغلة في القدم، ونتيجة لقرب الشواطئ برقة لجزر البحر الأبيض المتوسط، فقد نشأت تجارية بين القبائل وجزيرة كريت وكانت قبيلة المشوش على اتصال بالشردن لمدة سبعين عاماً قبل تحالفهم مع الليبيين عهد الفرعون مرنبتاح . شعوب هم وقبائل هندو اوروبية هاجرت من شرق شمال أوروبا، وشرق بحر قزوين واواسط آسيا دفعات متتالية إلى شبه جزيرة البلقان ( اليونان)، وإلى سواحل وجزر ايجه وتض...