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BACKGROUND Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odd...
In the course of our studies on enzyme inhibitors produced by microorganisms, two potent esterase inhibitors named ebelactone A and B, were isolated from the cultured broth of the strain MG7-G1 which was closely related to Streptomyces aburaviensis1). They were determined to be new members of mycolic acid /3-lactone. As reported in our previous papers2.3), esterastin, an esterase inhibitor prod...
PREFACE .......................................................................................327 I. OVERVIEW .......................................................................................327 II. SOLITARY CONFINEMENT CAN CAUSE SEVERE PSYCHIATRIC HARM .......................................................................................333 A. Solitary Confinement Can Cause a Specific ...
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Leong et ai. Ecological Entomology. 17:338-342, 1992. Altizer et ai. J. Invert. Path. 74:76-88, 1999. Leong et ai. J. Invertebrate Pathology 69:79-83, Jan. 1997. Leong et ai. Pan-Pacific Entomologist 73(1):49-51, 1997. Leong et aI., "The occurrence and effect of a protozoan parasite, Ophryocystis elektroscirrha (Neogregarinida: Ophryocystidae) on overwintering monarch butterflies, Danaus Plexip...
Miniature inverted-repeat transposable elements (MITEs) are ubiquitous in high eukaryotic genomes. More than 178,000 MITE sequences of 338 families are present in the genome of rice (Oryza sativa) cultivar Nipponbare. Interestingly, only two of the 338 MITE families have homologous sequences in the genome of Brachypodium distachyon, a relative in the grass family. Therefore, the vast majority o...
BACKGROUND Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, endoscopic pneumatic dilation (PD), laparoscopic Heller myotomy (LHM), and per-oral endoscopic myot...
Although acotiamide hydrochloride hydrate (acotiamide-HH) has not been reported to have genotoxic findings in any of the genotoxicity studies or treatment-related toxicological findings in reproductive and developmental studies, suspicious uterine tumorigenesis was observed in the results of a long-term rat carcinogenicity study. To clarify the uterine tumorigenesis of acotiamide-HH, we perform...
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