Oxidative stress is linked to many pathological conditions including the loss of dopaminergic neurons in Parkinson's disease. The vast majority of disease cases appear to be caused by a combination of genetic mutations and environmental factors. We screened for genes protecting Caenorhabditis elegans dopaminergic neurons from oxidative stress induced by the neurotoxin 6-hydroxydopamine (6-OHDA)...

Caffeine (CAF) ingestion may enhance endurance exercise by lowering perceived exertion (RPE) and muscle pain. However, exercise in the heat may be detrimental to performance by increasing RPE and pain. The purpose of this study was to examine if caffeine affects pain and related perceptual responses differently in cool and hot ambient conditions. Eleven male cyclists (mean ± SD; age, 25 ± 6 yea...

BACKGROUND Aim of this study was to compare post resuscitation care of out-of-hospital cardiac arrest (OHCA) patients in Nordic (Denmark, Finland, Iceland, Norway, Sweden) intensive care units (ICUs). METHODS An online questionnaire was sent to Nordic ICUs in 2012 and was complemented by an additional one in 2014. RESULTS The first questionnaire was sent to 188 and the second one to 184 ICU...

Diversifying aquaculture in Saudi Arabia with the inclusion of finfish species already reared Mediterranean Sea requires a sufficient understanding preferences and limits cultured fish under local conditions. This study was conducted using three species, juveniles (135–155g), meager (Argyrosomus regius), European seabass (Dicentrarchus labrax), greater amberjack (Seriola dumerili), to assess th...

UNLABELLED Clinical question In unconscious patients of out-of-hospital cardiac arrest, does targeted temperature management to 36°C (96.8°F) improve outcomes compared to the standard target of 32°C-34°C (89.6°F-93.2°F)? Article chosen Nielson N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013;369:2197-2206. OBJECTIV...

The enzymatic cyclization reaction of polyprenoid C(33) by squalene-hopene cyclase (SHC) was investigated with the intention of creating an unnatural hexacyclic compound. The enzymatic products consisted of mono-, bi-, tri-, tetra- and pentacyclic skeletons; however, hexacyclic products were not generated, contrary to our expectations. The absence of a hexacyclic skeleton indicated that the ent...

IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of IL-33 pretreatment on anti-fungal response using an acute Candida albicans peritoneal infection model. IL-33 pretreatment induced a rapid fungal clearance and markedly reduced the C. albicans infection-associated mortality. The priming effect of IL-33 occurred during multiple steps of the neut...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. This deficiency in erythrocytes has a prevalence of 0.51 +/- 0.109 in the Caucasoid male population of Portugal. The frequency for deficiency-conferring genes is 0.39% in the Portuguese population. In the herein study populations males from areas of Portugal presenting with the highest prevalence of G6PD d...